Lysine functionalized nanodiamonds as gene carriers - Investigation of internalization pathways and intracellular trafficking

Alwani, Saniya; Hua, QingYun; Iftikhar, Safa; Appathurai, Narayan; Michel, Deborah; Karunakaran, Chithra; Badea, Ildikó

doi:10.1016/j.diamond.2019.107477

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…Zeta potential and particle size results indicated minimal sedimentation and good stability. According to the results, functionalizing NDs with lysine maintained their long-term stability and made it possible for them to interact with physiological systems [89].…”

Section: Aminationmentioning

confidence: 99%

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

Dey,

Ghosh,

Sanyal

et al. 2024

Biomed. Mater.

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In terms of biomedical tools, nanodiamond (ND) is a more recent innovation. Their size ranged from 4 to 100 nm. ND is produced via a variety of methods and is known for its physical toughness, durability, and chemical stability. The study revealed that surface modifications and functionalization have a significant influence on the optical and electrical properties of the nanomaterial. ND's surface functional groups have applications in a variety of domains, including drug administration, gene delivery, immunotherapy for cancer treatment, and bio-imaging to diagnose cancer. The biocompatibility of a material is critical for in vivo and in vitro interventions. This review focuses on recent advances in the methods of ND synthesis and ND-assisted drug delivery, moving through studies in cellular and animal models and bio-imaging for other biomedical applications. Furthermore, the prognosis of its clinical translation is being studied.

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Section: Aminationmentioning

confidence: 99%

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

Dey,

Ghosh,

Sanyal

et al. 2024

Biomed. Mater.

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Biodistribution of nanodiamonds is determined by surface functionalization

Rai

Alwani

Khan

et al. 2023

Diamond and Related Materials

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Properties, mechanism and applications of diamond as an antibacterial material

et al. 2021

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antibiotic resistance in bacteria is a current threat causing an increasing number of infections of difficult clinical management. While the overuse and misuse of antibiotics are investigated to reduce them, the need for alternatives to approaches is rising. carbon-based materials shown recent moderate to high antibacterial properties and diamond, thanks to its superior mechanical, tribological, electrical, chemical and biological quality is a choice material to investigate for safe antibacterial films, coatings and particles. here, the antibacterial properties of diamond films, nanodiamonds, Dlc films and a comprehensive list of the composites developed from them are discussed along with a summary of the bacterial strains used and the most efficient composition and/or concentration discovered. in a later stage, the mechanisms of action and the parameters that are believed to influence them are discussed and finally, an overview of the biomedical and food industry applications is given.

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Lysine functionalized nanodiamonds as gene carriers - Investigation of internalization pathways and intracellular trafficking

Cited by 4 publications

References 35 publications

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer

Biodistribution of nanodiamonds is determined by surface functionalization

Properties, mechanism and applications of diamond as an antibacterial material

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