Lysis Block Treatment: A New Form of Local Thrombolysis

Martin, Michael; T, Heimig; Fiebach, B. J. O.; Magnus, L.; Riedel, Christa

doi:10.1177/000331979404500210

Cited by 15 publications

(9 citation statements)

References 2 publications

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“…14 rt-PA has already successfully been used in patients with deep venous thrombosis and arterial occlusion, [15][16][17] pulmonary embolism, 18 and acute coronary artery thrombosis. 19,20 There is also a case report of successful intraoperative thrombolysis of microarterial occlusion by selective rt-PA infusion.…”

Section: Discussionmentioning

confidence: 99%

Microvascular repair following a modified crush-avulsion injury in a rat model: Effect of recombinant human tissue-type plasminogen activator on the patency rate

et al. 2000

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The failure rate of replantations following a crush-avulsion type injury is high. This study has been designed to reproduce an effective standardized crush-avulsion injury model to the femoral artery of the rat and evaluate the antithrombotic efficacy of systemic intravenous administration of recombinant human tissue-type plasminogen activator (rt-PA). The crush-avulsion injury was reproduced by using a bulldog clamp and two hemostats and followed by microvascular repair. The animals were divided into three groups of 20 rats each and received either normal saline, heparin 100 U/kg body weight, or rt-PA 3.5 mg/kg body weight intravenously. Patency tests were performed 20 min and 48 h after blood flow reestablishment. Results showed that this experimental crush-avulsion injury model ensures low patency in the control group, whereas systemic rt-PA administration improves the patency rate statistically significantly compared to control and heparin groups at both 20 min and 48 h postrevascularization.

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Section: Discussionmentioning

confidence: 99%

Microvascular repair following a modified crush-avulsion injury in a rat model: Effect of recombinant human tissue-type plasminogen activator on the patency rate

et al. 2000

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“…The remaining patients had no history of genital ulceration caused by HSVZ. A matched serum sample from each patient was tested for HSVl & 2 antibodies at Public Health Service Laboratory, Colindale using a published method (3).…”

Section: Seroprevalence Of Hsv2 Infection Using a Riba Type Specific mentioning

confidence: 99%

“…(1) there are defects in the retaining mechanisms for these (2) the deficient desquamation may relate to the higher-than- (3) the increased suceptibility of AD to develop skin infections These defects are to be regarded as part of the spectrum of abnormality in the genetics expressed as the disorder of atopic dermatitis. valuable trace elements in the atopic skin.…”

Section: [ Q Ureaplasma and Mycoplasma Infections In Patients With Nomentioning

confidence: 99%

Free Communications

1998

Acad Dermatol Venereol

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“…Due to the prolonged duration of ischemic symptoms and the very distal location of the arterial occlusions, we decided to apply thrombolytic therapy locally into the right forearm by the transvenous lysisblock technique on days 3 and 8 after presentation. 5 The applied thrombolytic cocktail contained 250,000 IU urokinase, 1,500 IU unfractionated heparin, and 2.5 mL 1% lidocaine dissolved in 30 mL of 0.9% saline solution. This treatment was well tolerated after systemic opiate analgesia and resulted in clinically significant improvement, as the tenderness subsided and the ulcers healed uneventfully.…”

mentioning

confidence: 99%