Lysolecithin acyltransferase of human plasma: Assay and characterization of enzyme activity

Subbaiah, Papasani V.

doi:10.1016/0076-6879(86)29105-3

Cited by 14 publications

(2 citation statements)

References 12 publications

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“…The compounds are derived from phosphatidylcholine (PC), also called lecithin, mainly catalyzed by lecithin-cholesterol acyltransferase (LCAT) [26]. Within high-density lipoproteins (HDL), LCAT catalyzes the transacylation of the fatty acid residue of PC to free cholesterol, which subsequently results in the formation of LysoPC and cholesterol ester [27]. Eight LysoPCs of various lengths and glycerophosphocholine were decreased in patients’ serum metabolic profiling, along with the decrement of total cholesterol, LDL, HDL, TSF and body fat content.…”

Section: Discussionmentioning

confidence: 99%

The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis

Yin

Zhang

et al. 2017

PLoS ONE

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The liver is essential for the regulation of energy, protein and amino acids, as well as in other aspects of metabolism. To identify efficient indexes for evaluation of nutritional status and metabolic characteristics during different Child-Pugh stages of hepatitis B cirrhosis, 83 patients and 35 healthy individuals were enrolled in our study. We found that grip strength, triceps skinfold thickness (TSF), body fat and skeletal muscle of the patients were reduced compared to the control group (P<0.05). Ultra-high-performance liquid chromatography data combined with mass spectrometry (UPLC-MS) showed that levels of a variety of metabolites, including lysophosphatidylcholines (LysoPCs), glycerophosphocholine, ornithine and glucuronic acid were reduced in the serum of patients with hepatitis B cirrhosis (P<0.001). However, glycerophosphoserine and taurocholic acid levels were higher than in the control group (P<0.001). Moreover, grip strength was correlated with the Child-Pugh score (P<0.05). Serum albumin, total cholesterol, LDL, LysoPCs, glycerophosphocholine, ornithine, glucuronic acid, glycerophosphoserine and taurocholic acid were correlated with the Child-Pugh score (P<0.01). These findings suggested that grip strength and the above small molecular substances might be considered as sensitive and important indexes for evaluating nutritional status and metabolic characteristics of patients with hepatitis B cirrhosis, which may help assess prognosis and adjust nutritional treatment.

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Section: Discussionmentioning

confidence: 99%

The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis

Yin

Zhang

et al. 2017

PLoS ONE

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“…However, serum albumin also binds lysophospholipids, mainly lysophosphatidylcholine (LysoPC), also called lysolecithin. It has been known for years that LysoPC is produced by lecithin cholesterol acyl transferase as a result of transferring, within high-density lipoproteins (HDL), the acyl chain from the sn -2 position of HDL-PC to free cholesterol, producing cholesterylester and LysoPC; the latter is further transferred to albumin [10]. The resulting LysoPC has a saturated acyl chain at the sn -1 position.…”

Section: Targeting the Brain With Choline Phospholipidsmentioning

confidence: 99%

DHA Metabolism: Targeting the Brain and Lipoxygenation

et al. 2010

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Docosahexaenoic acid (DHA), the end-product of the metabolism of omega-3 family fatty acids, is the main polyunsaturated fatty acid of the brain, but its accumulation is incompletely understood. This paper reviews how it could accumulate through specific uptake of DHA-containing lysophosphatidylcholine (LysoPC-DHA). DHA migrates very easily from the sn-2 position of LysoPC, which could be considered as the physiological form of polyunsaturated LysoPC, to the sn-1 position, which is much more stable. An approach preventing migration by acetylating the sn-1 position, while retaining the main physico-chemical properties of the carrier, is described. Also, the double lipoxygenation and bond-isomerization of DHA into 10(S),17(S)-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid, named PDX, by soybean lipoxygenase is described. As in other E,Z,E conjugated trienes, PDX is shown to inhibit human blood platelet aggregation at submicromolar concentrations.

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Phosphatidylcholine-sterol O-acyltransferase

Springer Handbook of Enzymes

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Lysolecithin acyltransferase of human plasma: Assay and characterization of enzyme activity

Cited by 14 publications

References 12 publications

The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis

The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis

DHA Metabolism: Targeting the Brain and Lipoxygenation

Phosphatidylcholine-sterol O-acyltransferase

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