Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia‐inducible factor‐1α and the PI3K pathway

Yang, Kun; Zheng, Danhua; Duan, Xiaoli; Bai, Lin; Xu, Yan; Cong, Yu Sheng

doi:10.1002/jcb.21919

Cited by 30 publications

(21 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[25,26] Furthermore, HIF-1α resulted in elongation of telomeres as a key transactivator for the induction of TERT transcription. [27] Simultaneously, some SNPs in ACYP2 have been identified to be associated with telomere length. [7,9,28,29] Subsequently, we performed a multivariate analysis adjusted for age and gender among HAPE patients and controls to investigate the association between ACYP2 genetic polymorphism and HAPE risk.…”

Section: Discussionmentioning

confidence: 99%

Association between genetic polymorphism of telomere-associated gene ACYP2 and the risk of HAPE among the Chinese Han population

Zhu

Liu

et al. 2017

Medicine

View full text Add to dashboard Cite

High-altitude pulmonary edema (HAPE) is a hypoxia-induced, life-threatening, pulmonary edema, which is characterized by exaggerated pulmonary hypertension caused by stress failure. ACYP2 was found to associated with telomere length, the aim of this study was to identify whether ACYP2 polymorphisms increase or decrease HAPE risk in the Chinese Han individuals.In present study, we have genotyped 7 single-nucleotide polymorphisms (SNPs) in ACYP2 to determine the haplotypes in a case–control study with 265 HAPE patients and 303 healthy individuals. Genotypes were determined using the Sequenom MassARRAY method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression with adjustment for gender and age. We found 3 SNPs yielded significant evidence for association with HAPE risk which had not been investigated before. Rs6713088 was found to have a 1.85- and 1.30-fold increased risk of HAPE in the recessive and additive model. The GT of rs843752 also conferred an increased risk of HAPE (GT/TT: OR = 1.51, 95% CI: 1.05–2.16, P = 0.026) and the genotype frequency distributions of rs843752 had significant difference between cases and controls. The CC genotype of rs17045754 had a protect effect on HAPE patients, and it was found to have a 0.29-fold reduced risk of HAPE in the recessive model.Although additional, larger population-based studies are needed to confirm these findings, our study shed light on the association between ACYP2 variant and HAPE risk in Han Chinese population for the first time.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between genetic polymorphism of telomere-associated gene ACYP2 and the risk of HAPE among the Chinese Han population

Zhu

Liu

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…Exposure to hypoxia has been shown to activate telomerase due to its ability to increase TERT expression, which in turn results in telomere elongation [17,18]. The mechanisms responsible for hypoxia-induced TERT expression have been investigated, and it was shown that TERT expression was upregulated following the induction of HIF-1α during exposure to hypoxia and HIF-1α acted as an essential transactivator to induce TERT transcription [19-21]. …”

Section: Discussionmentioning

confidence: 99%

Telomeres are elongated in rats exposed to moderate altitude

Wang¹,

Zhou

Yang³

et al. 2014

J Physiol Anthropol

View full text Add to dashboard Cite

BackgroundLeukocyte telomere length has been shown to be associated with life span. Hypoxia-associated changes of telomere length have been detected in cell cultures, but no in vivo studies have reported the changes of telomere length under different hypoxic conditions. This study aimed to evaluate the effects of altitude on telomere length in rat leukocytes.MethodsOne hundred and ten male Wistar rats were randomized into 3 groups and maintained at sea-level (altitude of 10 m) (SL group, n = 10), moderate altitude (2,260 m) (MA group, n = 50), or simulated high altitude (5,000 m (SHA group, n = 50). The last two groups were further divided into 5 subgroups and exposed to hypoxia for 1, 3, 7, 15, or 30 days (n = 10). The leukocyte telomere length, hemoglobin concentration, red blood cell count, hematocrit, and plasma levels of telomerase reverse transcriptase (TERT), hypoxia-inducible factor 1α (HIF-1α), malondialdehyde (MDA) and superoxide dismutase (SOD) were measured.ResultsLeukocyte telomere length was significantly longer in the MA group than in the SL or SHA groups, and the TERT expression changed in a similar manner as the leukocyte telomere length. However, HIF-1α level was significantly higher in both MA and SHA groups than the SL group. SOD level was decreased and MDA level was elevated in SHA group.ConclusionsThe telomere length of blood leukocytes is elongated at a moderate altitude, but not at a high altitude. A mild hypoxic state may increase telomere length.

show abstract

“…As well as inhibition of apoptosis, one of the hallmarks of cancer is the avoidance of senescence. LPA suppresses p53-dependant replicative senescence (Kortlever et al 2008), at least in part through induction of telomerase (Bermudez et al 2007;Yang et al 2008). Along with many other chemotherapeutic agents, carboplatin and paclitaxel induce apoptosis.…”

Section: Lpa/autotaxin and Inhibition Of Apoptosis And Chemoresistancementioning

confidence: 99%

Autotaxin – A Target for the Treatment of Drug-Resistant Ovarian Cancer?

King-Underwood¹,

Allin²,

Redman³

et al. 2012

Ovarian Cancer - Basic Science Perspective

View full text Add to dashboard Cite

Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia‐inducible factor‐1α and the PI3K pathway

Cited by 30 publications

References 44 publications

Association between genetic polymorphism of telomere-associated gene ACYP2 and the risk of HAPE among the Chinese Han population

Association between genetic polymorphism of telomere-associated gene ACYP2 and the risk of HAPE among the Chinese Han population

Telomeres are elongated in rats exposed to moderate altitude

Autotaxin – A Target for the Treatment of Drug-Resistant Ovarian Cancer?

Contact Info

Product

Resources

About