2005
DOI: 10.1074/jbc.m410455200
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Lysophosphatidic Acid (LPA) Protects Primary Chronic Lymphocytic Leukemia Cells from Apoptosis through LPA Receptor Activation of the Anti-apoptotic Protein AKT/PKB

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Cited by 54 publications
(50 citation statements)
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“…Activation of Akt protects primary lymphocytic leukemia cells and ovarian cancer cells from apoptosis, whereas G i -mediated activation of MAPK is necessary for the survival of fibroblasts [13,14,64]. In these fibroblasts, the PI3K-Akt pathway showed a limited contribution to the survival activity of LPA [13].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Activation of Akt protects primary lymphocytic leukemia cells and ovarian cancer cells from apoptosis, whereas G i -mediated activation of MAPK is necessary for the survival of fibroblasts [13,14,64]. In these fibroblasts, the PI3K-Akt pathway showed a limited contribution to the survival activity of LPA [13].…”
Section: Discussionmentioning
confidence: 99%
“…The varied effects of LPA on apoptosis are dependent on the presence of specific LPA receptors, but also on the cellular context. For example, activation of LPA 1 prevented apoptosis in primary lymphocytic leukemia cells, whereas the same LPA 1 induced apoptosis and anoikis in ovarian cancer cells [14,15]. In untransformed rat intestinal epithelial IEC-6 cells, both LPA 1 and LPA 2 are thought to be responsible for the anti-apoptotic effect of LPA [16], but the effect in colon cancer cells is not known.…”
Section: Introductionmentioning
confidence: 99%
“…Previously it has been demonstrated that in primary chronic lymphocytic leukemia cells in which the LPA 1 receptor is upregulated, LPA protects cells from spontaneous apoptosis through an LPA 1 -dependent activation of AKT/PKB pathways (36). In contrast, in IEC-6 intestinal epithelial cells that express high levels of LPA 2 and lesser amounts of LPA 1 , an LPA 2 -selective agonist, FAP-12, protects cells from camptothecin-induced apoptosis (37).…”
Section: Discussionmentioning
confidence: 99%
“…[3][4][5] This kinase is also activated in response to many other microenvironmental stimuli that increase leukemic cell survival or induce proliferation, including CXCL12, CD40 ligand, IL-4, CpG oligonucleotides, lysophosphatidic acid, high-density lipoprotein particles and contact with bone marrow stromal cells. [6][7][8][9][10][11][12][13] In addition, increased basal Akt activity has been reported in some studies, suggesting that constitutive Akt signaling may contribute to the increased survival of the malignant lymphocytes. In line with this possibility, specific inhibition or downregulation of Akt has been shown to induce apoptosis in freshly isolated CLL cells.…”
Section: Introductionmentioning
confidence: 97%