2024
DOI: 10.1002/cbin.12192
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Lysophosphatidylcholine induces oxidative stress and calcium‐mediated cell death in human blood platelets

Pooja Yadav,
Samir K. Beura,
Abhishek R. Panigrahi
et al.

Abstract: Platelets are essential component of circulation that plays a major role in hemostasis and thrombosis. During activation and its demise, platelets release platelet‐derived microvesicles, with lysophosphatidylcholine (LPC) being a prominent component in their lipid composition. LPC, an oxidized low‐density lipoprotein, is involved in cellular metabolism, but its higher level is implicated in pathologies like atherosclerosis, diabetes, and inflammatory disorders. Despite this, its impact on platelet function rem… Show more

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