Lysosomal-associated membrane protein-2 plays an important role in the pathogenesis of primary cutaneous vasculitis

Takeuchi, Sora; Kimura, Satoko; Soma, Yoshinao; Waki, Masashi; Yamaguchi, M; Nakazawa, Daigo; Tomaru, Utano; Ishizu, Akihiro; Kawakami, Tamihiro

doi:10.1093/rheumatology/ket159

Cited by 16 publications

(9 citation statements)

References 23 publications

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“…There have been few studies on biomarkers in polyarteritis nodosa. Autoantibodies against lysosomal-associated membrane protein-2 (LAMP-2) showed an association with dermatological signs of the disease, but in the end there was no significant difference when compared to values measured in healthy controls (66). LAMP-2 is a component of the lysosomal membrane.…”

Section: Medium Vessel Vasculitismentioning

confidence: 94%

“…LAMP-2 is a component of the lysosomal membrane. It has been assumed that LAMP-2 plays a role in the pathogenesis of vasculitis (66). Mechanistically, Takeuchi et al hypothesize that anti-LAMP-2-antibodies bind to neutrophils, which then infiltrate small vessels of the skin (66).…”

Section: Medium Vessel Vasculitismentioning

confidence: 99%

“…It has been assumed that LAMP-2 plays a role in the pathogenesis of vasculitis (66). Mechanistically, Takeuchi et al hypothesize that anti-LAMP-2-antibodies bind to neutrophils, which then infiltrate small vessels of the skin (66). The main limitation of the study consists in the fact that the association with LAMP-2-antibodies seems to exclusively refer to cutaneous manifestation.…”

Section: Medium Vessel Vasculitismentioning

confidence: 99%

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Biomarkers in Vasculitides of the Nervous System

et al. 2019

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Besides being affected by the rare and severe primary angiitis of the central nervous system (PACNS) the nervous system is also affected by primary systemic vasculitides (PSV). In contrast to PACNS, PSV affect not only the central but also the peripheral nervous system, resulting in a large array of potential symptoms. Given the high burden of disease, difficulties in distinguishing between differential diagnoses, and incomplete pathophysiological insights, there is an urgent need for additional precise diagnostic tools to enable an earlier diagnosis and initiation of effective treatments. Methods available to date, such as inflammatory markers, antibodies, cerebrospinal fluid (CSF) analysis, imaging, and biopsy, turn out to be insufficient to meet all current challenges. We highlight the use of biomarkers as an approach to extend current knowledge and, ultimately, improve patient management. Biomarkers are considered to be useful for disease diagnosis and monitoring, for predicting response to treatment, and for prognosis in clinical practice, as well as for establishing outcome parameters in clinical trials. In this article, we review the recent literature on biomarkers which have been applied in the context of different types of nervous system vasculitides including PACNS, giant-cell arteritis, Takayasu's arteritis, polyarteritis nodosa, ANCA (anti-neutrophil cytoplasm antibody)-associated vasculitides, cryoglobulinemic vasculitis, IgA vasculitis, and Behçet's disease. Overall, the majority of biomarkers is not specific for vasculitides of the nervous system.

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Section: Medium Vessel Vasculitismentioning

confidence: 94%

Section: Medium Vessel Vasculitismentioning

confidence: 99%

Section: Medium Vessel Vasculitismentioning

confidence: 99%

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Biomarkers in Vasculitides of the Nervous System

et al. 2019

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“…Autoantibodies to the LAMP-2 protein were recently found to be associated with cutaneous PAN [25], but concentrations overlapped enough with those of healthy controls that this antibody is unlikely to be useful diagnostically.…”

Section: Polyarteritis Nodosa and Central Nervous System Vasculitismentioning

confidence: 99%

Biomarkers in vasculitis

Monach

2014

Current Opinion in Rheumatology

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Purpose of review Better biomarkers are needed for guiding management of patients with vasculitis. Large cohorts and technological advances had led to an increase in pre-clinical studies of potential biomarkers. Recent findings The most interesting markers described recently include a gene expression signature in CD8+ T cells that predicts tendency to relapse or remain relapse-free in ANCA-associated vasculitis, and a pair of urinary proteins that are elevated in Kawasaki disease but not other febrile illnesses. Both of these studies used “omics” technologies to generate and then test hypotheses. More conventional hypothesis-based studies have indicated that the following circulating proteins have potential to improve upon clinically available tests: pentraxin-3 in giant cell arteritis and Takayasu’s arteritis; von Willebrand factor antigen in childhood central nervous system vasculitis; eotaxin-3 and other markers related to eosinophils or Th2 immune responses in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome); and MMP-3, TIMP-1, and CXCL13 in ANCA-associated vasculitis. Summary New markers testable in blood and urine have the potential to assist with diagnosis, staging, assessment of current disease activity, and prognosis. However, the standards for clinical usefulness, in particular the demonstration of either very high sensitivity or very high specificity, have yet to be met for clinically relevant outcomes.

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“…Cyclophosphamide decreases the immune system's response to various diseases, including vasculitis. We suggested that several autoantibodies such as antilysosomal‐associated membrane protein‐2 antibodies and antiphosphatidylserine–prothrombin complex antibodies could be closely related to the pathogenesis of CA in our previous studies . We encountered two patients with refractory CA associated with arthritis and mononeuritis multiplex, with elevated serum CRP.…”

mentioning

confidence: 91%