Lysosome-targeted ruthenium(II) complex encapsulated with pluronic® F-127 induces oncosis in A549 cells

Pan, Nanlian; Zhang, Yuqing; Huang, Minying; Liang, Zhijun; Gong, Yao; Chen, Xide; Li, Yuling; Wu, Ciling; Huang, Zunnan; Sun, Jing

doi:10.1007/s00775-023-02039-5

J Biol Inorg Chem

2024

DOI: 10.1007/s00775-023-02039-5

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Lysosome-targeted ruthenium(II) complex encapsulated with pluronic® F-127 induces oncosis in A549 cells

Nanlian Pan,

Yuqing Zhang,

Minying Huang

et al.

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Cited by 4 publications

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Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Chen,

Liang,

Gong

et al. 2024

ChemBioChem

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Mitochondrial viscosity has emerged as a promising biomarker for diseases such as cancer and neurodegenerative disorders, yet accurately measuring viscosity at the subcellular level remains a significant challenge. In this study, we synthesized and characterized three cyclometalated iridium(III) complexes (Ir1‐Ir3) containing 5‐fluorouracil derivatives as ligands. Among these, Ir1 selectively induced apoptosis in HeLa cells by increasing mitochondrial production of reactive oxygen species (ROS), which triggered a cascade of events leading to mitochondrial dysfunction. Additionally, the fluorescence lifetime of Ir1 demonstrated high sensitivity to intracellular viscosity changes, enabling real‐time fluorescence lifetime imaging microscopy (FLIM) of cellular micro‐viscosity during apoptosis. These findings underscore the potential of cyclometalated Ir(III) complexes for both therapeutic and diagnostic applications at the subcellular level.

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Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Chen,

Liang,

Gong

et al. 2024

ChemBioChem

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Unraveling Mechanism and Enhancing Selectivity of a Ru^II‐bis‐bipyridyl‐morphocumin Complex with RAFT‐Generated Glycopolymer Exploiting Warburg Effect in Cancer

Roy,

Paul,

Mukherjee

et al. 2024

Chemistry A European J

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Warburg effect, generates increased demand of glucose in cancer but is relatively underexplored phenomenon in existing commercial anti‐cancer drugs. Here, we present a Ru(II)‐bis‐bipyridyl‐morphocumin complex (2) encapsulated in a self‐assembling glucose‐functionalized co‐polymer P(G‐EMA‐co‐MMA) (where G = glucose; MMA = methyl methacrylate; EMA = ethyl methacrylate), designed to exploit Warburg effect and enhance cancer selectivity. The P(G‐EMA‐co‐MMA) polymer, synthesized via reversible‐addition fragmentation chain transfer (RAFT) polymerization, has a number average molecular weight (Mn, NMR) of 8000 g/mol. Complex 2, stable in aqueous media, selectively releases a cytotoxic, lysosome‐targeting compound morphocumin in the presence of excess H2O2, a reactive oxygen species (ROS) prevalent in tumor microenvironments. Complex 2 promotes ROS accumulation enhancing morphocumin release through a synergistic domino effect. Comparatively, 2 outperforms its curcumin Ru(II) complex (1) in solution stability, organelle specificity, and cellular mechanisms. Both 1 and 2 exhibit phototherapeutic effects under low‐intensity visible light, but their dark toxicity surpasses their photoactivity, highlighting they are superior as chemotherapeutic agents. Complex 2 induces apoptosis via mitochondrial pathway with 9‐fold increase in selectivity for pancreatic cancer cells (MIA PaCa‐2) over non‐cancerous HEK293 cells when delivered encapsulated in glucose‐conjugated polymer (DP@2)activity enhance further 5‐fold by glucose deprivation underscoring their potential in targeted cancer therapy.

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Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy

Rodrigues,

Kiran,

Chatterjee

et al. 2025

Biochemical Pharmacology

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Lysosome-targeted ruthenium(II) complex encapsulated with pluronic® F-127 induces oncosis in A549 cells

Cited by 4 publications

References 55 publications

Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Unraveling Mechanism and Enhancing Selectivity of a Ru^II‐bis‐bipyridyl‐morphocumin Complex with RAFT‐Generated Glycopolymer Exploiting Warburg Effect in Cancer

Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy

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Lysosome-targeted ruthenium(II) complex encapsulated with pluronic® F-127 induces oncosis in A549 cells

Cited by 4 publications

References 55 publications

Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Unraveling Mechanism and Enhancing Selectivity of a RuII‐bis‐bipyridyl‐morphocumin Complex with RAFT‐Generated Glycopolymer Exploiting Warburg Effect in Cancer

Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy

Contact Info

Product

Resources

About

Unraveling Mechanism and Enhancing Selectivity of a Ru^II‐bis‐bipyridyl‐morphocumin Complex with RAFT‐Generated Glycopolymer Exploiting Warburg Effect in Cancer