Lysozyme-sensitive plasmonic hydrogel nanocomposite for colorimetric dry-eye inflammation biosensing

Ziai, Yasamin; Rinoldi, Chiara; Petronella, Francesca; Zakrzewska, Anna; De Sio, Luciano; Pierini, Filippo

doi:10.1039/d4nr01701c

Nanoscale

2024

DOI: 10.1039/d4nr01701c

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Lysozyme-sensitive plasmonic hydrogel nanocomposite for colorimetric dry-eye inflammation biosensing

Yasamin Ziai,

Chiara Rinoldi,

Francesca Petronella

et al.

Abstract: Multi-layered hydrogel-based plasmonic photothermal-responsive nanoplatforms were fabricated for lysozyme biosensing in human tears. Visual color change of the system in a colorimetric assay and shifts in the absorption LSPR revealed their potential.

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Cited by 2 publications

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Mechanism of hierarchical plasmonic biomaterials engineered through peptide‐directed self‐assembly

Amer,

Retout,

Jin

et al. 2024

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Hierarchical plasmonic biomaterials constructed from small nanoparticles (NPs) that combine into larger micron‐sized structures exhibit unique properties that can be harnessed for various applications. Using diffusion‐limited aggregation (DLA) and defined peptide sequences, we developed fractal silver biomaterials with a Brownian tree structure. This method avoids complex redox chemistry and allows precise control of interparticle distance and material morphology through peptide design and concentration. Our systematic investigation revealed how peptide charge, length, and sequence impact biomaterial morphology, confirming that peptides act as bridging motifs between particles and induce coalescence. Characterization through spectroscopy and microscopy demonstrated that arginine‐based peptides are optimal for fractal assembly based on both quantitative and qualitative measurements. Additionally, our study of diffusion behavior confirmed the effect of particle size, temperature, and medium viscosity on nanoparticle mobility. This work also provides insights into the facet distribution in silver NPs and their assembly mechanisms, offering potential advancements in the design of materials for medical, environmental, and electronic applications.

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Mechanism of hierarchical plasmonic biomaterials engineered through peptide‐directed self‐assembly

Amer,

Retout,

Jin

et al. 2024

Aggregate

View full text Add to dashboard Cite

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Combining Electrospinning and Photoinduced Reactions to Fabricate Cytocompatible and Antibacterial Ag Nanoparticle-Decorated Polymeric Membranes

Kianfar,

Dalle Vacche,

Bongiovanni

et al. 2024

ACS Appl. Polym. Mater.

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Composite nanofibrous membranes hold significant potential for the development of innovative biomedical materials and applications as their properties can be tuned by combining the synergistic effects of the nanofiller and the polymer matrix. Moreover, the nanofibrous structure can further enhance this feature thanks to the extremely high functional surface area. In the present work, a simple and fast method for the preparation of electrospun composite membranes based on cross-linked poly(ethylene oxide) (PEO) nanofibers and silver nanoparticles (Ag NPs) is proposed. For this purpose, a precursor of the Ag NPs (i.e., AgNO 3 ) is introduced into the aqueous solution of PEO in the presence of a suitable photoinitiator and a photo-cross-linker. Electrospinning of the solution is carried out, and the subsequent irradiation of the electrospun mat allows the simultaneous photoinduced cross-linking of PEO and the photoinduced synthesis of Ag NPs. The in situ generation of Ag NPs is confirmed through different characterization techniques (i.e., UV−vis spectroscopy, dynamic light scattering, and scanning electron microscopy). The structural, morphological, and mechanical properties of the resulting electrospun composite nanofibers are analyzed, and the effect of the content of the Ag NP precursor is evaluated. It is demonstrated that PEO fibers are chemically resistant and mechanically robust thanks to cross-linking, while Ag NPs induce significant antibacterial activity to the electrospun materials, which are also shown to be noncytotoxic by using both human fibroblasts and 3D-reconstructed skin equivalents. The proposed PEO-based nanofibrous mats decorated with Ag NPs thus exhibit promising potential as biomedical materials, especially for wound healing applications.

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Lysozyme-sensitive plasmonic hydrogel nanocomposite for colorimetric dry-eye inflammation biosensing

Abstract: Multi-layered hydrogel-based plasmonic photothermal-responsive nanoplatforms were fabricated for lysozyme biosensing in human tears. Visual color change of the system in a colorimetric assay and shifts in the absorption LSPR revealed their potential.

Cited by 2 publications

References 36 publications

Mechanism of hierarchical plasmonic biomaterials engineered through peptide‐directed self‐assembly

Mechanism of hierarchical plasmonic biomaterials engineered through peptide‐directed self‐assembly

Combining Electrospinning and Photoinduced Reactions to Fabricate Cytocompatible and Antibacterial Ag Nanoparticle-Decorated Polymeric Membranes

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