Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration

Nozaki, Ryunosuke; Kasamatsu, Atsushi; Moss, Joel; Uzawa, Katsuhiro

doi:10.1016/j.bbrc.2021.11.100

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…The myosin-X knockout mouse is semilethal and shows defects in filopodial formation; melanoblast migration; and eye, limb, and brain development (Bachg et al 2019, Heimsath et al 2017. Other functions for myosin-X-induced filopodia have been found in myoblast fusion (Hammers et al 2021) and fibroblast migration in wound healing (Nozaki et al 2022). Because of its multiple domains, it is unclear which functions of myosin-X (organization of actin filaments, cargo transport, or direct force production) are directly involved in promoting filopodial formation and at which stage it acts (Houdusse & Titus 2021).…”

Section: Actin Motors In Filopodiamentioning

confidence: 99%

Filopodia In Vitro and In Vivo

Blake

Gallop

2023

Annu. Rev. Cell Dev. Biol.

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Filopodia are dynamic cell surface protrusions used for cell motility, pathogen infection, and tissue development. The molecular mechanisms determining how and where filopodia grow and retract need to integrate mechanical forces and membrane curvature with extracellular signaling and the broader state of the cytoskeleton. The involved actin regulatory machinery nucleates, elongates, and bundles actin filaments separately from the underlying actin cortex. The refined membrane and actin geometry of filopodia, importance of tissue context, high spatiotemporal resolution required, and high degree of redundancy all limit current models. New technologies are improving opportunities for functional insight, with reconstitution of filopodia in vitro from purified components, endogenous genetic modification, inducible perturbation systems, and the study of filopodia in multicellular environments. In this review, we explore recent advances in conceptual models of how filopodia form, the molecules involved in this process, and our latest understanding of filopodia in vitro and in vivo. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 39 is October 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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