“…This relates to i) identification of one or more individual molecular species of peroxidized CLs (CLox) from their highly diversified multiple forms accumulating during apoptosis (Domingues et al, 2008; Ji et al, 2012; Tyurin et al, 2010; see Tyurina et al, in this issue), and ii) the necessity and identity of potential protein partners engaged in the formation of a “pore” in the OMM through which pro-apoptotic factors are liberated into the cytosol (Bender and Martinou, 2013). While complexes of CLs and CLox with several OMM and intermembrane space proteins –Bcl-2 family proteins, VDAC, cyt c – have been suggested to play a role in apoptotic membrane permeabilization and pore formation (Korytowski et al, 2011; Rostovtseva and Bezrukov, 2008; Veenman et al, 2008; Xu et al, 2013), neither specific mechanisms nor physiological role of these interactions have been firmly established. Moreover, there are indications that sequestration of CLox molecules occurring without participation of any proteins may lead to the formation of pores large enough to allow for the release of pro-apoptotic factors (Jurkiewicz et al, 2012).…”