Lytic effector cell activity and major depressive disorder in patients with breast cancer: a prospective study

Sachs, Gabriele; Rasoul‐Rockenschaub, Susanne; Aschauer, Harald; Spiess, Klaus; Göber, I; Staffen, A; Zielinski, C. C.

doi:10.1016/0165-5728(95)00029-2

Cited by 44 publications

(23 citation statements)

References 28 publications

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“…The relevance of depression is characterized: severely depressed was proved in 5 of all 25 subjects, the moderately depressed in 10 subjects of all 25 subjects and mildly depressed in 10 of all 25 subjects. The results of our prospective study supports Sneeuw´s [12] and Sachs´s [13] overview work. Both authors [12,13] present that cancer types highly associated with depression include breast (1,5-46%).…”

Section: Discussionsupporting

confidence: 80%

“…The results of our prospective study supports Sneeuw´s [12] and Sachs´s [13] overview work. Both authors [12,13] present that cancer types highly associated with depression include breast (1,5-46%). Pinder et al [14] found a 13 % prevalence of depression in advanced breast cancer patients (N=139), increased levels of depression were found in those with lowest socioeconomic status, poorest performance status, and closer proximity to death.…”

Section: Discussionsupporting

confidence: 80%

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Depression symptoms and health-related quality of life among patients with metastatic breast cancer in programme of palliative cancer care

Slováček¹,

Slováčková²,

Slánská³

et al. 2009

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Depression is seen in many cancer patients. It occurs in approximately 25% of palliative care patients. The quality of life term contains the information on an individual´s physical, psychological, social and spiritual condition.The study evaluated incidence and relevance of depression symptoms and level of health-related quality of life (HRQoL) among patients with metastatic breast cancer in programme of palliative cancer care.This study was local, prospective and cross-sectional. It was carried at Department of Clinical Oncology and Radiation Therapy of Charles University Hospital in Hradec Králové, Czech Republic. Dates were obtained during year 2008 among 41 patients with metastatic breast cancer in programme of palliative cancer care. The mean age for all 41 subjects was 58 years old (aged 41 -80 years old). The Czech version of Zung self-rating depression scale was perfomed for evaluation of depression symptoms. The Czech version of generic EuroQol Questionnaire EQ-5D was performed for evaluation of level of HRQoL.The statistical evaluation presents that mean ZSDS (Zung self-rating depression score) certifies the presence of signs of moderately depression symptoms among patients with metastatic breast cancer (ZSDS range was 60-69). The mean ZSDS in all subjects was 60,6. The mean ZSDS in group of healthy females was 38,9 (normal range of ZSDS). The incidence of depression was 61% (25 of all 41 subjects). The relevance of depression is characterized: severely depressed was proved in 5 of all 25 subjects, the moderately depressed in 10 subjects of all 25 subjects and mildly depressed in 10 of all 25 subjects. The statistical evaluation not presents statistically significant dependence of ZSDS on age, number of associated diseases and type of palliative cancer care. The HRQoL among patients with metastatic breast cancer is on very low level. The mean EQ-5D score (dimension of quality of life) was 55%. The mean EQ-5D VAS (subjective health condition) was 59,2%. The mean EQ-5D score in group of healthy females was 78,4% and the mean EQ-5D VAS was 85% (both QoL parameters show very good of QoL level). The statistical evaluation not presents statistically significant dependence of EQ-5D score and EQ-5D VAS on age, number of associated diseases and type of palliative cancer care.The results showed that subsist clear association between metastatic breast cancer in programme of palliative cancer care and depression. Also, the results showed that subsist low level of HRQoL of patients with metastatic breast cancer.Key words: metastatic breast cancer, programme of palliative cancer care, depression, health-related quality of life.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 80%

Depression symptoms and health-related quality of life among patients with metastatic breast cancer in programme of palliative cancer care

Slováček¹,

Slováčková²,

Slánská³

et al. 2009

neo

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“…1 Furthermore, psychological distress is highly prevalent, and up to 57% of breast cancer patients experience depression and anxiety. [2][3][4][5] As a result, access to supportive intervention is a critical component of cancer care at any time patients are experiencing distress across the spectrum of diagnosis, treatment, and survivorship.…”

Section: Introductionmentioning

confidence: 99%

Animal-Assisted Therapy and Counseling Support for Women With Breast Cancer

et al. 2015

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Background. Animal-assisted therapy (AAT) interventions have been shown to assist in coping and improve patient responses to symptoms. Specifically, the presence of an animal has been found to lower anxiety and motivate participation in therapy. We aimed to explore the acceptability of and experience of AAT during individual breast cancer counseling sessions. Methods. Patients undertaking counseling with a therapy dog present were invited to participate in the study. Patients were individually interviewed and asked to reflect on their experiences of AAT. Data generation and analysis were concurrent. Transcripts were analyzed thematically using a process of constant comparison. Results. Our sample included 8 female participants, 39 to 61 years old, at an average of 3 years post-breast cancer diagnosis. The majority of patients reported a positive experience with AAT. Themes that emerged around their counseling experience included benefits in the process of initiating counseling and benefits for greater engagement and personal disclosure. Conclusions. Incorporating AAT into the delivery of counseling for breast cancer patients appears to be feasible and acceptable at a patient level. From a clinical perspective, AAT promoted increased communication with health professionals. This is of clinical importance as a means to improve participation and engagement in therapy-important elements in therapeutic outcomes. However, further evaluation of the impact of AAT on specific patient outcomes and psychological morbidity is required.

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“…A systematic review reported the median prevalence of depression in advanced cancer patients was 29% using the Hospital Anxiety and Depression Scale [238], while another study found 57% of ambulatory palliative care cancer patients self-reported depression [239]. Depression was documented in as many as 46% of breast cancer patients [240,241], although this number was not as high in hematologic cancer patients (17.5%) [242]. Stage and treatment status…”

Section: Antidepressant Usementioning

confidence: 99%