M

Considine, Douglas M.; Considine, Glenn D.

doi:10.1007/978-1-4684-8511-0_13

Cited by 2 publications

(1 citation statement)

References 259 publications

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“…It has been postulated that leptin functions as a sensor of fat mass and as a hormonal signal which exerts its anorectic effect through its hypothalamic receptor (8)(9)(10). Indeed, plasma leptin levels are closely correlated with body weight and fat mass in rodents and humans (9,11).…”

Section: Introductionmentioning

confidence: 99%

Leptin selectively decreases visceral adiposity and enhances insulin action.

et al. 1997

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Intraabdominal adiposity and insulin resistance are risk factors for diabetes mellitus, dyslipidemia, arteriosclerosis, and mortality. Leptin, a fat-derived protein encoded by the ob gene, has been postulated to be a sensor of energy storage in adipose tissue capable of mediating a feedback signal to sites involved in the regulation of energy homeostasis. Here, we provide evidence for specific effects of leptin on fat distribution and in vivo insulin action. Leptin (LEP) or vehicle (CON) was administered by osmotic minipumps for 8 d to pair-fed adult rats. During the 8 d of the study, body weight and total fat mass decreased similarly in LEP and in CON. However, while moderate calorie restriction (CON) resulted in similar decreases in whole body (by 20%) and visceral (by 21%) fat, leptin administration led to a specific and marked decrease (by 62%) in visceral adiposity. During physiologic hyperinsulinemia (insulin clamp), leptin markedly enhanced insulin action on both inhibition of hepatic glucose production and stimulation of glucose uptake. Finally, leptin exerted complex effects on the hepatic gene expression of key metabolic enzymes and on the intrahepatic partitioning of metabolic fluxes, which are likely to represent a defense against excessive storage of energy in adipose depots. These studies demonstrate novel actions of circulating leptin in the regulation of fat distribution, insulin action, and hepatic gene expression and suggest that it may play a role in the pathophysiology of abdominal obesity and insulin resistance.

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Section: Introductionmentioning

confidence: 99%

Leptin selectively decreases visceral adiposity and enhances insulin action.

et al. 1997

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Effects of different level of leaf removal applications on mineral substance of raisins in organic Sultani Çekirdeksiz grape growing

Ateş¹,

Ünal²,

Takma³

et al. 2016

BIO Web Conf.

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Abstract. 311.595 hectares of organic grapes are grown, which constitutes 4.6 percent of the world's grape growing area.Turkey is a major producer country of grapes growing in the world. Viticulture is one of the major branches of agriculture with respect to production area and its largest are of income in Turkish national economy. Since 1985, Turkey producing and exporting organic raisins, is a world leader in the production of raisins.8418 hectares grape are grown organically which constitutes 1.8% of the total grape production area of Turkey.The research was carried out in Alaşehir-Yeşilyurt Enterprise of Manisa Viticulture Research Institute in West Turkey from 2006 to 2007. In this study, effect of four different level of leaf removal applications at two periods on mineral substance of raisins at Sultani Ç ekirdeksiz grape variety growing organic conditions were investigated.Experiment design were planed randomized block trial design with three replicates consisting of 12 vines per parcel were established. Mineral substance analyses of the raisins obtained from the applications were performed using the ICP-AES technique.It was found that there was highest average potassium (K), iron (Fe) and Zinc (Zn) contents of the raisin in removing two leaves at berry set time down to the clusters; highest average magnesium (Mg) and copper (Cu) contents of the raisin in removing two leaves down to the clusters and removing two leaves up to the clusters at verasion time; highest average phosphorus (P) contents of the raisin in no leaf removal; highest average sodium (Na) contents of the raisin in removing three leaves at the berry set time and removing three leaves at verasion time down and up to the clusters at 5% significant level.

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M

Cited by 2 publications

References 259 publications

Leptin selectively decreases visceral adiposity and enhances insulin action.

Leptin selectively decreases visceral adiposity and enhances insulin action.

Effects of different level of leaf removal applications on mineral substance of raisins in organic Sultani Çekirdeksiz grape growing

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