M Cell in the Immune System of the Lung

Pankow, W; Wichert, P. v.

doi:10.1159/000195527

Cited by 28 publications

(9 citation statements)

References 22 publications

(30 reference statements)

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“…BALT is similar to GALl" (i.e., Peyer's patches) in that it is an organized aggregate of B and T lymphocytes, macrophages, and other immunocompetent cells covered by a specialized epithelium containing M cells (12). M cells overlaying BALT are distinct from typical ciliated cells of the airway epithelium in that they are flattened with irregular microfolds at the apical surface (13,14). Previously, it has been shown that ferritin and horseradish peroxidase (HRP) can be taken up by pulmonary M cells and transported into BALT (15,16).…”

Section: Resultsmentioning

confidence: 99%

A pathway for entry of reoviruses into the host through M cells of the respiratory tract.

Morin

Warner

Fields

1994

The Journal of Experimental Medicine

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SummaryMany microorganisms gain access to the systemic circulation after entering the respiratory tract. The precise pathways used to cross the mucosal barriers of the lungs have not been clearly described. We have used the mammalian reoviruses in order to determine the pathway that a systemic virus uses to penetrate the mucosal barrier and enter the systemic circulation after entering the airways of the lungs. Reoviruses enter through pulmonary M cells, which overlie bronchus-associated lymphoid tissue, and subsequently spread to regional lymph nodes. Thus, the pathway through M cells represents a strategy by which viruses and probably other microorganisms can penetrate the mucosal surface of the respiratory tract and thereby enter the systemic circulation.

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Section: Resultsmentioning

confidence: 99%

A pathway for entry of reoviruses into the host through M cells of the respiratory tract.

Morin

Warner

Fields

1994

The Journal of Experimental Medicine

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“…Indeed, bronchial Microfold (M) cells have been shown to translocate M.tb from the mucosa, enabling dissemination to the lymphatics [19,20]. Thus M cells, located in the nasal and bronchus-associated lymphoid tissue (NALT/BALT) [19,21], are positioned to participate in generating an early protective immune response against M.tb infection [19,20]. …”

Section: Mtb Transit Through the Respiratory Systemmentioning

confidence: 99%

Integrating Lung Physiology, Immunology, and Tuberculosis

Torrelles

Schlesinger

2017

Trends in Microbiology

113

101

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Lungs are directly exposed to the air, have enormous surface area and enable gas exchange in air-breathing animals. They are constantly “attacked” by microbes from both outside and inside and thus possess a unique, highly regulated local immune defense system which efficiently allows for microbial clearance while minimizing damaging inflammatory responses. As a prototypic host-adapted airborne pathogen, Mycobacterium tuberculosis traverses the lung and has several ‘interaction points (IPs)’ which it must overcome to cause infection. These interactions are critical, not only from a pathogenesis perspective but also in considering the effectiveness of therapies and vaccines in the lungs. Here we discuss emerging views on immunologic interactions occurring in the lungs for M. tuberculosis and their impact on infection and persistence.

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“…It is located mainly at branching sites such as the bifurcations of the bronchial tree. It was found that the respiratory epithelium overlaying the bronchial lymphoid structures contains M cells that are flattened and devoid of cilia [114][115][116][117]. The BALT shows high variability between species and although constitutive structures are seen in rabbits and rats, this is not the case in humans [118,119].…”

Section: Bronchus-associated Lymphoid Tissuementioning

confidence: 99%

Pulmonary DNA vaccination: Concepts, possibilities and perspectives

Bivas-Benita

Ottenhoff

Junginger

et al. 2005

Journal of Controlled Release

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Mucosal immunity establishes the first line of defence against pathogens entering the body via mucosal surfaces. Besides eliciting both local and systemic immunity, mucosal vaccination strategies that are non-invasive in nature may increase patient compliance and reduce the need for vaccine application by trained personnel. A relatively new concept is mucosal immunization using DNA vaccines. The advantages of DNA vaccines, such as the opportunity to combine the genetic information of various antigen epitopes and stimulatory cytokines, the enhanced stability and ease of production make this class of vaccines attractive and suitable for mucosal application. In contrast to the area of intranasal vaccination, only a few recent studies have focused on pulmonary immunization and the involvement of the pulmonary immune system in eliciting protective immune responses against inhaled pathogens. This review focuses on DNA vaccine delivery to the lung as a promising approach to prevent pulmonary-associated diseases caused by inhaled pathogens. Attractive immunological features of the lung as a site for immunization, the mechanisms of action of DNA vaccines and the pulmonary application of such vaccines using novel delivery systems will be discussed. We also examine pulmonary diseases prone to prevention or therapeutical intervention by application of DNA vaccines.

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M Cell in the Immune System of the Lung

Cited by 28 publications

References 22 publications

A pathway for entry of reoviruses into the host through M cells of the respiratory tract.

A pathway for entry of reoviruses into the host through M cells of the respiratory tract.

Integrating Lung Physiology, Immunology, and Tuberculosis

Pulmonary DNA vaccination: Concepts, possibilities and perspectives

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