M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation

Kandalla, Prashanth K.; Sarrazin, Sandrine; Molawi, Kaaweh; Berruyer-Pouyet, Carole; Redelberger, David; Favel, Anne; Bordi, Christophe; Bentzmann, Sophie de; Sieweke, Michael H.

doi:10.1084/jem.20151975

Cited by 45 publications

(57 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The requirement of recipient Mw for sustained engraftment of long-term HSCs in the BM suggests that an approach to expand recipient Mws before or immediately after transplant may improve transplantation outcomes. Recent experimental models 13,48 and older clinical trials 49,50 using the Mw growth factor CSF1 support this proposal. One previous study suggested utility of CSF1 in allotransplantation, even though the dose of recombinant CSF1 used was only marginally active in mice.…”

Section: Discussionmentioning

confidence: 95%

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Kaur

Raggatt

Millard

et al. 2018

Blood

View full text Add to dashboard Cite

Distinct subsets of resident tissue macrophages are important in hematopoietic stem cell niche homeostasis and erythropoiesis. We used a myeloid reporter gene (-eGFP) to dissect the persistence of bone marrow and splenic macrophage subsets following lethal irradiation and autologous hematopoietic stem cell transplantation in a mouse model. Multiple recipient bone marrow and splenic macrophage subsets survived after autologous hematopoietic stem cell transplantation with organ-specific persistence kinetics. Short-term persistence (5 weeks) of recipient resident macrophages in spleen paralleled the duration of extramedullary hematopoiesis. In bone marrow, radiation-resistant recipient CD169 resident macrophages and erythroid-island macrophages self-repopulated long-term after transplantation via autonomous cell division. Posttransplant peak expansion of recipient CD169 resident macrophage number in bone marrow aligned with the persistent engraftment of phenotypic long-term reconstituting hematopoietic stem cells within bone marrow. Selective depletion of recipient CD169 macrophages significantly compromised the engraftment of phenotypic long-term reconstituting hematopoietic stem cells and consequently impaired hematopoietic reconstitution. Recipient bone marrow resident macrophages are essential for optimal hematopoietic stem cell transplantation outcomes and could be an important consideration in the development of pretransplant conditioning therapies and/or chemoresistance approaches.

show abstract

Section: Discussionmentioning

confidence: 95%

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Kaur

Raggatt

Millard

et al. 2018

Blood

View full text Add to dashboard Cite

show abstract

“…Some molecular principles of adaptation of myelopoiesis and hematopoiesis during infections are emerging. During a variety of systemic inflammatory conditions, such as acute shock, infection with Ehrlichia species, or bacteria induced sepsis models, G-CSF, M-CSF, and interferon serve as major regulators of inflammatory myelopoiesis (Buechler et al, 2016;Kandalla et al, 2016;Karmaus et al, 2017;Mitroulis et al, 2018b). This is attributed to their ability to target and activate the mTOR pathway, inducing glycolysis and triggering enhanced myelopoiesis.…”

Section: Myelopoiesis In the Face Of Major Infectionsmentioning

confidence: 99%

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

2019

View full text Add to dashboard Cite

Myelopoiesis ensures the steady state of the myeloid cell compartment. Technological advances in fate mapping and genetic engineering, as well as the advent of single cell RNA-sequencing, have highlighted the heterogeneity of the hematopoietic system and revealed new concepts in myeloid cell ontogeny. These technologies are also shedding light on mechanisms of myelopoiesis at homeostasis and at different phases of infection and inflammation, illustrating important feedback loops between affected tissues and the bone marrow. We review these findings here and revisit principles in myelopoiesis in light of the evolving understanding of myeloid cell ontogeny and heterogeneity. We argue for the importance of system-wide evaluation of changes in myelopoiesis and discuss how even after the resolution of inflammation, long-lasting alterations in myelopoiesis may play a role in innate immune memory or trained immunity.

show abstract

“…Data from animal models suggest that M-CSF may also play a role in controlling invasive fungal infections [39]. However, it has never been tested in humans and unlike G-CSF and GM-CSF, there is no pharmaceutical product available.…”

Section: Cytokine Therapymentioning

confidence: 99%

Modulating host immune responses to fight invasive fungal infections

Scriven

Tenforde

Levitz

et al. 2017

Current Opinion in Microbiology

View full text Add to dashboard Cite

Modulation of host immunity in invasive fungal infection is an appealing but as yet mostly elusive treatment strategy. Animal studies in invasive candidiasis and aspergillosis have demonstrated beneficial effects of colony stimulating factors, interferon-gamma and monoclonal antibodies. More recent studies transfusing leukocytes pre-loaded with lipophilic anti-fungal drugs, or modulated T-cells, along with novel vaccination strategies show great promise. The translation of immune therapies into clinical studies has been limited to date but this is changing and the results of new Candida vaccine trials are eagerly awaited. Immune modulation in HIV-associated mycoses remains complicated by the risk of immune reconstitution inflammatory syndrome and although exogenous interferon-gamma therapy may be beneficial in cryptococcal meningitis, early initiation of anti-retroviral therapy leads to increased mortality. Further study is required to better target protective immune responses.

show abstract

M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation

Abstract: Sieweke and colleagues show that M-CSF/CSF-1 treatment after myeloablation and hematopoietic stem/progenitor cell transplantation results in increased production of mature myeloid donor cells and protects against opportunistic pathogens.

Cited by 45 publications

References 40 publications

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

Modulating host immune responses to fight invasive fungal infections

Contact Info

Product

Resources

About