M-mode photoacoustic particle flow imaging

Fang, Hui; Wang, Lihong V.

doi:10.1364/ol.34.000671

Cited by 37 publications

(30 citation statements)

References 18 publications

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“…A mixture of particles with various sizes will not impact the measurement. This is different from the case in which only a single illumination point or strip is present, [4][5][6] where the transit time depends on the illumination spot size, the particle speed, and the particle size. Within the optical diffusion limit, although tissue scattering of light may reduce the modulation depth and blur the fringe pattern, the pitch period is maintained.…”

Section: Methodsmentioning

confidence: 80%

“…1 Blood flow measurement by photoacoustic (PA) imaging is gaining interest, as it takes advantage of weak acoustic scattering and high optical absorption contrast. [2][3][4][5][6][7] Compared with ultrasound Doppler imaging, PA flow measurement has superior detection sensitivity. Depending on acoustic scattering, Doppler ultrasound suffers from a lack of sensitivity to red blood cells (RBCs), especially in measuring slow blood flow (<1 mm∕s).…”

Section: Introductionmentioning

confidence: 99%

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Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media

Yao¹,

Gilson

Maslov

et al. 2014

J. Biomed. Opt

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Abstract. We propose a calibration-free photoacoustic (PA) method for transverse flow measurements. In this method, a pulsed periodically structured (i.e., grating patterned) optical beam is used to illuminate flowing absorptive particles in an optically scattering medium. The PA signal amplitudes measured over consecutive laser pulses carry an imprint of the illumination structure. The modulation frequency of the imprint is proportional to the component of the flow speed projected onto the normal axis of the striped illumination pattern. This method can tolerate high particle density, and is insensitive to the particle size, thus calibration-free. Bovine blood and microsphere phantoms were used to validate the proposed method. Blood flow in a mouse ear was measured in vivo as well.

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Section: Methodsmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media

Yao¹,

Gilson

Maslov

et al. 2014

J. Biomed. Opt

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“…100,101 Moreover, PADF can detect the flow only along the ultrasonic axis. 102 To image transverse flow and slow capillary flow, Fang and Wang 102 developed an M-mode photoacoustic particle imaging velocimetry based on OR-PAM. A similar configuration was previously employed by Zharov et al [103][104][105] and Galauzha et al 106 for counting circulating cells in vivo.…”

Section: Photoacoustic Flow Measurementmentioning

confidence: 99%

Photoacoustic imaging and characterization of the microvasculature

2010

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Abstract. Photoacoustic ͑optoacoustic͒ tomography, combining optical absorption contrast and highly scalable spatial resolution ͑from micrometer optical resolution to millimeter acoustic resolution͒, has broken through the fundamental penetration limit of optical ballistic imaging modalities-including confocal microscopy, two-photon microscopy, and optical coherence tomography-and has achieved high spatial resolution at depths down to the diffusive regime. Optical absorption contrast is highly desirable for microvascular imaging and characterization because of the presence of endogenous strongly light-absorbing hemoglobin. We focus on the current state of microvascular imaging and characterization based on photoacoustics. We first review the three major embodiments of photoacoustic tomography: microscopy, computed tomography, and endoscopy. We then discuss the methods used to characterize important functional parameters, such as total hemoglobin concentration, hemoglobin oxygen saturation, and blood flow. Next, we highlight a few representative applications in microvascular-related physiological and pathophysiological research, including hemodynamic monitoring, chronic imaging, tumor-vascular interaction, and neurovascular coupling. Finally, several potential technical advances toward clinical applications are suggested, and a few technical challenges in contrast enhancement and fluence compensation are summarized.

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“…Fang and Wang used a PAM, but in optical resolution mode to estimate the transit time of particles flowing through the optical focus [66]. This transit time, when combined with the size of the focus provided an estimation for the lateral flow velocity as can be seen in Figure 5.7.…”

Section: Transit-time Flow Imaging Of Single-particlesmentioning

confidence: 99%

“…They noticed a slower speed when GNRs were bound, arguing that unbound GNRs would flow in the centre of the tubing and these heavier cells would not. Besides investigating this transit time technique, Sarimallaoglu et al also used [66,67]: The time during which a cell or a particle is visible is determined by the speed at which it transits the optical focus.…”

Section: Transit-time Flow Imaging Of Single-particlesmentioning

confidence: 99%

Integrated photoacoustic/ultrasound imaging : Applications and new techniques

Berg

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M-mode photoacoustic particle flow imaging

Cited by 37 publications

References 18 publications

Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media

Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media

Photoacoustic imaging and characterization of the microvasculature

Integrated photoacoustic/ultrasound imaging : Applications and new techniques

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