2009
DOI: 10.1038/ncb1990
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M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

Abstract: Cell-cell communication is essential for the development and homeostasis of multicellular organisms. Recently, a new type of cell-cell communication was discovered that is based on the formation of thin membranous nanotubes between remote cells. These long membrane tethers, termed tunneling nanotubes (TNTs), form an intercellular conduit and have been shown to enable the transport of various cellular components and signals. However, the molecular basis for TNT formation remains to be elucidated. Here we report… Show more

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Cited by 319 publications
(443 citation statements)
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“…Figure 2C) [29]. In addition, Cdc42 also seems to be required for TNT elongation, since short protrusions of membrane tubules accumulate without further elongation in the presence of dominant negative Cdc42 [29].…”
Section: M-sec a Clue For Understanding The Molecular Mechanisms Of mentioning
confidence: 95%
See 2 more Smart Citations
“…Figure 2C) [29]. In addition, Cdc42 also seems to be required for TNT elongation, since short protrusions of membrane tubules accumulate without further elongation in the presence of dominant negative Cdc42 [29].…”
Section: M-sec a Clue For Understanding The Molecular Mechanisms Of mentioning
confidence: 95%
“…Our recent study has revealed that M-Sec is a central factor for membrane protrusion during TNT formation [29]. M-Sec was first identified as tumor necrosis factor alpha-induced protein 2 (TNFaip2, also called B94), but its function has long been unknown [30].…”
Section: M-sec a Clue For Understanding The Molecular Mechanisms Of mentioning
confidence: 99%
See 1 more Smart Citation
“…p53 activation or EGFR or Akt/PI3K/mTOR induces M-Sec overexpression, which together with RalA and the exocyst complex can trigger F-actin polymerization 23 and contributes to TNT development from the cell membrane (Figure 6f). The development of TNTs is a property of the initiating cells, however, at the same time, there may be some guidance receptors on the target cell surface or guidance molecules released by the target cells.…”
Section: Discussionmentioning
confidence: 99%
“…Sequences of primers for the M-Sec were as following: forward primer: (5 0 -GTGCAGAACCTCTACCCCAATG-3 0 ); and reverse primer: (5 0 -TGGAGAATGT CGATGGCCA-3 0 ). 23 Real-time PCR quantifications were run in triplicate for each sample and the average were determined. In order to use the comparative Ct method for relative quantification, the amplification efficiency of target and housekeeping gene must be approximately equal.…”
Section: Microinjection Thin-walledmentioning
confidence: 99%