M<sup>k</sup> and M<sup>g</sup>: Some Serological and Physicochemical Observations

Nordling, Stig; Sanger, Ruth; Gavin, June; Furuhjelm, U.; Myllylä, G.; Metaxas, M. N.

doi:10.1111/j.1423-0410.1969.tb00399.x

Cited by 40 publications

(16 citation statements)

References 5 publications

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“…Cells of the rare M N variants Mg, Mk (9,12), Miltenberger classes I I I and V (9), as well as cells lacking the public Ena antigen (5,9) and Tn polyagglutinable cells (1 1, 16), exhibit, in addition to their serologic abnormalities, aberrant values for membrane sialic acid content and electrophoretic mobility. In these abnormal cells, as well as in the case of neuraminidase-treated cells (4, lo), the Prinrrd rn U .…”

Section: Speculationmentioning

confidence: 99%

Comparison of Electrophoretic Mobility and Membrane Sialic Acid Content of Erythrocytes from Adult and Umbilical Cord Blood

Luner¹,

Szklarek²

1975

Pediatr Res

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Section: Speculationmentioning

confidence: 99%

Comparison of Electrophoretic Mobility and Membrane Sialic Acid Content of Erythrocytes from Adult and Umbilical Cord Blood

Luner¹,

Szklarek²

1975

Pediatr Res

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“…The idea is attractively simple, but the further idea that 'anti-Mk' sera react with an unconverted basic substance must be reconsidered in the light of the observations of Furuhjelm and co-workers on the extraordinary phenotype En(a-) and on En^En heterozygotes and of the parallel observations of Nordling and co-workers on Mk and Mg [2,10].…”

Section: Discussionmentioning

confidence: 99%

“…The true explanation was recently provided by Dr. Ruth Sanger, who showed that Mk cells have the general property, pre sumably due to a physico-chemical alteration of their surface, of being agglutinated in saline by incomplete Rh antisera corresponding to their Rh groups [10].…”

Section: So-called Anti-mkmentioning

confidence: 99%

“…The gene Mk can be recognized in the heterozygote (no homozygote has yet been found), although by quite different means than those which usually apply to blood group genes : instead of giving rise to an antigen readily defined by a specific antibody, Mk reveals its presence by a lack of antigens of the MN Ss system [5,9] and, as shown more recently [10], in other characteristics of the red cells which must be related to some abnormality of the surface of the latter. One expects such a gene to occur in half of the children of a mating in which one partner possesses it and the other does not.…”

mentioning

confidence: 99%

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The Inheritance of the Blood Group Gene M^k and Some Considerations on Its Possible Nature

Metaxas¹,

Metaxas-Bühler²,

Romanski³

1971

Vox Sanguinis

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Although the gene M^k gives rise to none of the antigens of the MN or Ss series, its presence is revealed in the heterozygous state by the results of dosage experiments and by certain reactions related to some abnormality of the red cell surface. The corresponding character M^k may therefore be considered as dominant, and in matings of the type Mk x non-M^k, half of the children should consequently inherit the gene, and the other half not. Seventeen matings of the type mentioned, and 5 more presumed to be of this type, were analyzed in this respect: the results correspond closely with expectation. Work on so-called anti-M^k sera is reviewed and the results are discussed in conjunction with considerations on the possible nature of the gene M^k. The conclusion is reached that these sera do not contain a true blood group antibody and that Mk is either an amorph or a ‘built-in’ inhibitor gene at the MNSs locus.

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“…Red cells having a decreased surface charge density (e.g. normal cells treated with proteolytic enzymes and untreated En(a-) [4], Mk and Ms cells [10]) are agglutinated more strongly by heterophilic antibodies in animal sera than are normal red cells. The animal sera reacted more strongly with RDE treated and papainized O-cells than with untreated OScells.…”

Section: Reaction Of Os-cells With Animal Seramentioning

confidence: 99%

Persistent Mixed Field Polyagglutinability

Myllylä¹,

Furuhjelm²,

Nordling³

et al. 1971

Vox Sanguinis

Self Cite

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The red cells of a 28-ycar-old healthy group 0 donor, Mr. O.S. (0Scells), have persisted, over 4 years of investigation, in showing mixed field polyagglutinability. About 50% of the red cells are agglutinated by the great majority of human sera from adults, by some seed and snail extracts and by the serum of various animals. The cells further show a certain affinity for anti-A reagents which can be distinguished from that of true A cells. The sialic acid content of the polyagglutinable fraction of the cells is decreased with consequent reduction in their electrophoretic mobility. Inhibition tests show that the disturbance involves N-acctyl-D-galactosamine. Both absorption and in vivo survival tests showed that not only the agglutinable but also the non-agglutinable cells are abnormal. The available family gives no clue to whether the condition is genetic. The polyagglutinable reaction of OS-cells, which is not due to anti-T but may be due to anti-Tn or an antibody at present indistinguishable from it, is compared with that of other types of polyagglutinability.

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M^k and M^g: Some Serological and Physicochemical Observations

Cited by 40 publications

References 5 publications

Comparison of Electrophoretic Mobility and Membrane Sialic Acid Content of Erythrocytes from Adult and Umbilical Cord Blood

Comparison of Electrophoretic Mobility and Membrane Sialic Acid Content of Erythrocytes from Adult and Umbilical Cord Blood

The Inheritance of the Blood Group Gene M^k and Some Considerations on Its Possible Nature

Persistent Mixed Field Polyagglutinability

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Mk and Mg: Some Serological and Physicochemical Observations

Cited by 40 publications

References 5 publications

Comparison of Electrophoretic Mobility and Membrane Sialic Acid Content of Erythrocytes from Adult and Umbilical Cord Blood

Comparison of Electrophoretic Mobility and Membrane Sialic Acid Content of Erythrocytes from Adult and Umbilical Cord Blood

The Inheritance of the Blood Group Gene M^k and Some Considerations on Its Possible Nature

Persistent Mixed Field Polyagglutinability

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Product

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M^k and M^g: Some Serological and Physicochemical Observations