2016
DOI: 10.1016/j.rvsc.2016.01.014
|View full text |Cite
|
Sign up to set email alerts
|

M1 and M2 macrophage recruitment during tendon regeneration induced by amniotic epithelial cell allotransplantation in ovine

Abstract: Recently, we have demonstrated that ovine amniotic epithelial cells (oAECs) allotransplanted into experimentally induced tendon lesions are able to stimulate tissue regeneration also by reducing leukocyte infiltration. Amongst leukocytes, macrophages (Mφ) M1 and M2 phenotype cells are known to mediate inflammatory and repairing processes, respectively. In this research it was investigated if, during tendon regeneration induced by AECs allotransplantation, M1Mφ and M2Mφ phenotype cells are recruited and differe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

3
86
1
1

Year Published

2016
2016
2024
2024

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 60 publications
(91 citation statements)
references
References 65 publications
3
86
1
1
Order By: Relevance
“…Altogether, these data strongly support the hypothesis that AECs provide therapeutic benefits during acute tendon healing (Barboni, Russo, et al, ; Mauro et al, ; Muttini et al, ; Muttini et al, ), thus reinforcing the clinical and preclinical evidences of their regenerative role through a direct use as native or amplified cells in regenerative medicine.…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…Altogether, these data strongly support the hypothesis that AECs provide therapeutic benefits during acute tendon healing (Barboni, Russo, et al, ; Mauro et al, ; Muttini et al, ; Muttini et al, ), thus reinforcing the clinical and preclinical evidences of their regenerative role through a direct use as native or amplified cells in regenerative medicine.…”
Section: Discussionsupporting
confidence: 78%
“…Moreover, the enhanced development of the inflammatory phase promoted by hAECs could represent another positive event leading to the early tendon healing that mimics what occurs when acute tendinopathies are promptly treated with anti‐inflammatory drugs (Richardson, Dudhia, Clegg, & Smith, ). First of all, as recently demonstrated in vivo for oAECs (Mauro et al, ), hAECs transplantation elicited a lower infiltration of leucocytes, T lymphocytes, and Mφ, thus confirming the in situ persistence of the inherited immunomodulatory activities demonstrated in vitro (Barboni, Russo, Curini, et al, ).…”
Section: Discussionsupporting
confidence: 76%
“…The fact that hAMTCs and CM could switch the differentiation of pro‐inflammatory M1‐macrophages into a M2 anti‐inflammatory/immune‐suppressive phenotype could reveal the beneficial effects observed in different in vivo models (Parolini et al , ; Silini et al , ). Indeed, macrophage‐mediated resolution has been observed after treatment with amniotic‐derived cells or MSCs from different sources in liver fibrosis (Manuelpillai et al , ), multiple sclerosis (Liu et al , ), lung fibrosis (Murphy et al , ; Cargnoni et al , ; Tan et al , ), tendon lesions (Mauro et al , ) and skin wound healing (Zhang et al , ).…”
Section: Discussionmentioning
confidence: 99%
“…In a highly conserved manner, these types of extra-fetal stem cells express SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81 embryonic markers and OCT4, SOX2, NANOG, and TERT pluripotent genes, which are responsible for their high plasticity [34]. AECs' immunomodulatory properties represent an important biological characteristic [35], as they can be successfully used in allo-and xeno-transplantation preclinical settings and clinical trials [32]. The natural inclination of AECs to undergo the Epithelial-Mesenchymal Transition (EMT) process [36] justifies their capacity to differentiate in vitro towards the mesenchymal lineage, as the tenogenic one, under adequate stimuli [33].…”
Section: Introductionmentioning
confidence: 99%