M1130 The Effects of Azathioprine or 6-Mercaptopurine On Birth Outcome in Women with Inflammatory Bowel Disease

In utero exposure to thiopurines/anti‐TNF agents and long‐term health outcomes during childhood and adolescence in Denmark

“…We know from a large number of papers that several autoimmune diseases, or the medications used to treat them, exert a negative impact on short-term birth outcomes such as preterm birth and small for gestational age, [5][6][7][8][9][10][11][12] and several studies have suggested a negative effect of in utero thiopurine exposure and short-term adverse perinatal outcomes. 4,9,[13][14][15][16] However, there is a lack on solid data on long-term outcomes of the offspring. [17][18][19][20][21] The few studies of long-term child health (beyond an age of 1 year) have been characterized by a small number of exposed children (N=15, 22 N=30, 23 and N=13 18 ), very different outcomes of interest, short follow up time during childhood, and lack of confounder control.…”