M1274 Diclofenac Encephalopathy, Liver and Gastrointestinal Lesions in Rat and Stable Gastric Pentadecapeptide BPC 157

Ilic, Spomenko; Drmic, Domagoj; Kolenc, Danijela; Čorić, Marijana; Brčić, Luka; Klicek, Robert; Radic, Bozo; Sever, Marko; Đuzel, Viktor; Filipović, Marinko; Ivica, Mihovil; Blagaić, Alenka Boban; Ani, Tomislav; Zoricic, Ivan; Gjurašin, Miroslav; Romić, Željko; Dzidic, Senka; Seiwerth, Sven; Sikirić, Predrag

doi:10.1016/s0016-5085(10)61700-3

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…. Paracetamol (PA) or acetaminophen, is a well‐known NSAI drug considered one of the most widely used analgesics in the world, although PA is extremely hepatotoxic . Caffeine (CA) is one of the most common adjuvant analgesic drug also found in many beverages such as coffee and cola drinks.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of caffeine, paracetamol, and ibuprofen in pharmaceutical formulations by high‐performance liquid chromatography with UV detection and by capillary electrophoresis with conductivity detection

Cunha

Chaves²,

Ribeiro

et al. 2015

J of Separation Science

View full text Add to dashboard Cite

Paracetamol, caffeine and ibuprofen are found in over-the-counter pharmaceutical formulations. In this work, we propose two new methods for simultaneous determination of paracetamol, caffeine and ibuprofen in pharmaceutical formulations. One method is based on high-performance liquid chromatography with diode-array detection and the other on capillary electrophoresis with capacitively coupled contactless conductivity detection. The separation by high-performance liquid chromatography with diode-array detection was achieved on a C18 column (250×4.6 mm(2), 5 μm) with a gradient mobile phase comprising 20-100% acetonitrile in 40 mmol L(-1) phosphate buffer pH 7.0. The separation by capillary electrophoresis with capacitively coupled contactless conductivity detection was achieved on a fused-silica capillary (40 cm length, 50 μm i.d.) using 10 mmol L(-1) 3,4-dimethoxycinnamate and 10 mmol L(-1) β-alanine with pH adjustment to 10.4 with lithium hydroxide as background electrolyte. The determination of all three pharmaceuticals was carried out in 9.6 min by liquid chromatography and in 2.2 min by capillary electrophoresis. Detection limits for caffeine, paracetamol and ibuprofen were 4.4, 0.7, and 3.4 μmol L(-1) by liquid chromatography and 39, 32, and 49 μmol L(-1) by capillary electrophoresis, respectively. Recovery values for spiked samples were between 92-107% for both proposed methods.

show abstract

Section: Introductionmentioning

confidence: 99%