M1893 Are Post-Orthotopic Liver Transplant Patients At Higher Risk for Post-ERCP-Pancreatitis?

The Incidence of Endoscopic Retrograde Cholangiopancreatography-Related Complications in Patients With Liver Transplant: A Meta-Analysis and Systematic Review

“…Brown et al conducted a retrospective study at the University of Cincinnati Medical Center in which a total of 98 ERCPs in 98 liver transplant patients treated with tacrolimus were evaluated for post-ERCP pancreatitis (PEP) [ 18 ]. Abu Rajab and Gan retrospectively reviewed 146 ERCPs in 146 liver transplant recipients at Tufts-New England Medical Center for PEP [ 19 ]. Singh performed a retrospective review of PEP at the University of Nebraska in 109 liver transplant patients that received 235 ERCPs [ 20 ].…”

“…Similarly, various studies of the included cohort reported several indications for ERCP. The three most common indications for post-transplant ERCP, among many, included bile duct strictures, bile leaks, and choledocholithiasis [ 5 , 13 - 15 , 19 , 22 , 24 ]. The wide variety of indications for both liver transplant and post-transplant ERCP allow for a more complete perspective of the therapeutic effects of ERCP in multiple populations with variable risks.…”

“…Since the first study discussed post-ERCP complications in 1990 by Sanna et al [ 14 ], 10 other studies were published to date which specifically analyzed PEP, bleeding, infection, and cholangitis [ 5 , 12 , 13 , 15 - 19 , 22 , 23 ]. The majority of these studies found the risk of these complications in liver transplant patients to be comparable to historically reported risk [ 25 - 27 ].…”

“…The characteristics of the studies used in the meta-analysis are shown in Table 1 [5,[12][13][14][15][16][17][18][19][20][21][22][23][24].…”

“…Fourteen studies met our inclusion criteria and were included in this analysis [5,[12][13][14][15][16][17][18][19][20][21][22][23][24]. These studies include a total of 3,192 ERCPs performed on 1,787 patients.…”