2010
DOI: 10.1016/s0016-5085(10)62047-1
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M1936 Chitinase 3-Like-1 Enhances Inflammation-Associated Tumorigenesis by Activating the β-Catenin/Wnt Signaling Pathway of CECs

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“…In addition, mRNA expression of CC-chemokines including CCL-2 (MCP-1) is highly upregulated in the colonic mucosa of IBD patients as well as in the AOM pretreated DSS-colitis model [ 22 24 ]. Our group recently identified that one of the mammalian chitinases, chitinase 3-like-1 (CHI3L1/YKL-40), is significantly upregulated in message and protein levels in the colonic mucosa of IBD patients with active inflammation as well as murine models of colitis, [ 14 ] and this molecule seems to play an active role in the neoplastic transformation of epithelial cells [ 25 , 26 ]. Therefore, inflammatory cell infiltration and their secreting soluble mediators are key players in regulating pre-neoplastic growth of CECs in colitis-associated tumorigenesis.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, mRNA expression of CC-chemokines including CCL-2 (MCP-1) is highly upregulated in the colonic mucosa of IBD patients as well as in the AOM pretreated DSS-colitis model [ 22 24 ]. Our group recently identified that one of the mammalian chitinases, chitinase 3-like-1 (CHI3L1/YKL-40), is significantly upregulated in message and protein levels in the colonic mucosa of IBD patients with active inflammation as well as murine models of colitis, [ 14 ] and this molecule seems to play an active role in the neoplastic transformation of epithelial cells [ 25 , 26 ]. Therefore, inflammatory cell infiltration and their secreting soluble mediators are key players in regulating pre-neoplastic growth of CECs in colitis-associated tumorigenesis.…”
Section: Introductionmentioning
confidence: 99%