M1973 High Prevalence of Human Papillomavirus in a Spanish Population with Esophageal Cancer

Junquera, Félix; Videla, Sebastián; Cañadas, Maria Paz; Darwich, Laila; Calvet, Xavier; Brullet, Enric; Lario, Sergio; Lázaro, María José Ramírez; Bauer, E; Sirera, Guillermo; Clotet, Bonaventura; Campo, Rafel

doi:10.1016/s0016-5085(09)62108-9

Cited by 1 publication

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“…Sixty-one studies had control groups comprising of normal tissue samples and were used in both the risk and prevalence analyses [12, 15, 21–78]. The 71 other studies contained either no control group or samples from controls with benign or structural oesophageal disease and were used only in the analysis of the prevalence of HPV DNA in OSCC [10, 13, 14, 20, 79–145]. In total, 13 795 oesophageal samples were included in the analysis, with 9291 as cases with established OSCC and 4504 as controls with normal oesophageal mucosa.…”

Section: Resultsmentioning

confidence: 99%

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Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis

2014

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The oncogenic potential of human papillomaviruses (HPV) is well known in the context of cervical carcinoma; however, their role in the development of oesophageal squamous cell carcinoma (OSCC) is less clear. We aimed to determine the extent of the association between HPV infection and OSCC. A comprehensive literature search found 132 studies addressing HPV and OSCC in human cases, and a meta-analysis was performed using a random-effects model. There was evidence of an increased risk of OSCC in patients with HPV infection [odds ratio (OR) 2·69, 95% confidence interval (CI) 2·05-3·54]. The prevalence of HPV in OSCC was found to be 24·8%. There was an increased risk associated with HPV-16 infection (OR 2·35, 95% CI 1·73-3·19). Subgroup analyses showed geographical variance, with Asia (OR 2·94, 95% CI 2·16-4·00), and particularly China (OR 2·85, 95% CI 2·05-3·96) being high-risk areas. Our results confirm an increase in HPV infection in OSCC cases.

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Section: Resultsmentioning

confidence: 99%

“…No language restrictions were used in either the search or study selection. There were four studies included which were not published in English [12][13][14][15]. A search for unpublished literature was not performed.…”

Section: Study Protocolmentioning

confidence: 99%