M2 macrophage-derived exosomes induce angiogenesis and increase skin flap survival through HIF1AN/HIF-1α/VEGFA control

Luo, Gaojie; Zhou, Zekun; Cao, Zheming; Huang, Chengxiong; Li, Cheng; Li, Xiaoxiao; Deng, Chao; Wu, Panfeng; Yang, Zhenni; Tang, Juyu; Qing, Liming

doi:10.1016/j.abb.2023.109822

Cited by 3 publications

(1 citation statement)

References 58 publications

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“…Glycolysis can "educate" macrophages into M2 type, which promotes their own growth, and inhibit M1 polarization with the characteristics of attacking tumor cells [ 28 ]. The macrophages M2 can also promote angiogenesis and tumor growth through HIF-1α, vascular endothelial growth factor (VEGF) and other factors [ 29 ]. This phenomenon leads to vascular system disorder and extremely hypoxic environment, which further limits the infiltration of immune cells.…”

Section: Discussionmentioning

confidence: 99%

Integration RNA bulk and single cell RNA sequencing to explore the change of glycolysis-related immune microenvironment and construct prognostic signature in head and neck squamous cell carcinoma

Nie,

Cao,

Yang

et al. 2024

Translational Oncology

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Section: Discussionmentioning

confidence: 99%

Integration RNA bulk and single cell RNA sequencing to explore the change of glycolysis-related immune microenvironment and construct prognostic signature in head and neck squamous cell carcinoma

Nie,

Cao,

Yang

et al. 2024

Translational Oncology

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Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications

Li,

Yang,

et al. 2024

Cel. Mol. Bioeng.

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Visualizing spatiotemporal pattern of vascularization by SWIR fluorescence imaging in a mouse model of perforator flap transplantation

Feng,

Chen,

et al. 2024

Preprint

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Vascularization as a spatiotemporally interlaced process involving angiogenesis and vascular remodeling, has seldom been investigated comprehensively regarding the interrelationship of the two intertwining but sequential processes. Here, a shortwave infrared (SWIR) fluorescence imaging strategy with quantum dots (QDs) is designed to dynamically visualize vascularization in vivo and in situ in a perforator transplantation mouse model. The vascularization process could be directly perceived from the established flap model with an optimal observation window at 10 min post-injection. Based on SWIR technology and image processing, it was revealed that temporally, angiogenesis lasted throughout 21 days after surgery while vascular remodeling took a dominant role after 14 days both in vivo and in situ. Moreover, four perforasomes of the flap in situ displayed spatially that Zone IV shortened the vascularization process with sufficient blood supply from the LDCIA, while Zone II recovered slowly from ischemia with a lack of blood supply owing to choke zone theory. This study pioneered to add novel cognition of spatiotemporal pattern of vascularization through visualizing angiogenesis and vascular remodeling simultaneously and dynamically, thus facilitating further investigation into the mechanisms behind vascularization.

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M2 macrophage-derived exosomes induce angiogenesis and increase skin flap survival through HIF1AN/HIF-1α/VEGFA control

Cited by 3 publications

References 58 publications

Integration RNA bulk and single cell RNA sequencing to explore the change of glycolysis-related immune microenvironment and construct prognostic signature in head and neck squamous cell carcinoma

Integration RNA bulk and single cell RNA sequencing to explore the change of glycolysis-related immune microenvironment and construct prognostic signature in head and neck squamous cell carcinoma

Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications

Visualizing spatiotemporal pattern of vascularization by SWIR fluorescence imaging in a mouse model of perforator flap transplantation

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