M3 but not M4 muscarinic receptors in the rostromedial tegmental nucleus are involved in the acquisition of morphine-induced conditioned place preference

Wu, Jing; Li, Xuhong; Zhou, Pan; Li, Xinwang

doi:10.1016/j.ejphar.2020.173274

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…Moreover, the stimulation of NMDA receptors had no significant effect on locomotion during the testing phase (Figure 6B). However, NMDA activates inhibitory neurons in the RMTg by stimulating excitatory outputs (Li et al., 2016; Wu et al., 2020). Therefore, the reduction of morphine response induced by NMDA may occur through an indirect mechanism (LHb‐RMTg [GABAergic]‐VTA [dopaminergic] pathway).…”

Section: Discussionmentioning

confidence: 99%

The role of NMDA glutamate receptors in the lateral habenula on morphine‐induced conditioned place preference in rats

Amohashemi

Reisi

Alaei

2023

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The lateral habenula (LHb) has received special attention due to its role in modulating motivated behavior, stress response, and rewarding and aversive stimuli through monoamine transmission. In the present study, the involvement of the N-methyl-Daspartate (NMDA) receptors of the LHb in the expression and acquisition phases of morphine-induced conditioned place preference (CPP) was studied in male rats. Bilateral injections of agonist/antagonist (MK-801) of NMDA receptor were performed during the conditioning sessions of the acquisition phase. In other separate groups, drugs were also injected into the LHb before the test session during the expression phase of CPP. A 5-day CPP bias paradigm was used to study the effect of injections of NMDA and MK-801 into the LHb on morphine reward-related behavior. Different doses of NMDA plus morphine reduced the CPP score during the acquisition phase, whereas MK-801 significantly increased conditioning scores during the acquisition phase of CPP. The injection of agonists and antagonists of NMDA receptors in LHb had no significant effect on CPP scores and locomotion during the expression phase of CPP, whereas the motor activity in the acquisition phase was affected by the drugs. The reduction effect of NMDA on the CPP scores during the acquisition phase was blocked by pretreatment with MK-801. Our findings also suggest that NMDA receptors in the LHb may be involved in the acquisition phase of morphine-induced CPP.

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Section: Discussionmentioning

confidence: 99%

The role of NMDA glutamate receptors in the lateral habenula on morphine‐induced conditioned place preference in rats

Amohashemi

Reisi

Alaei

2023

Synapse

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“…There are different lateral habenula populations projected to the ventral tegmental area or rostromedial tegmental nucleus; activating them separately may induce opposite effects on mesolimbic dopamine release. [ 18 ] It is possible that lateral habenula electrical stimulation with low intensity plus an ineffective dose of morphine induces morphine response through the lateral habenula-ventral tegmental area pathway. High-intensity electrical stimulation could attenuate morphine response through the polysynaptic pathway [ Figure 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…High-intensity electrical stimulation could attenuate morphine response through the polysynaptic pathway [ Figure 4 ]. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Low Current Intensity Plus an Ineffective Dose of Morphine Affect Conditioning Place Preference Through Different Pathways in the Lateral Habenula

Alaei¹,

Amohashemi²,

Reisi³

2023

Advanced Biomedical Research

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Background: The involvement of lateral habenula and the ineffective dose of morphine on reward-related learning and memory is less well-known. This study looked into the effects of electrical stimulation, GABA B receptor blockade, and a combination of both with morphine on conditioned place preference. Materials and Methods: In this experiment, male rats were anesthetized with ketamine/xylazine (six rats in each group). A 5-day biased conditioned place preference paradigm was used for the behavioral test. The effects of electrical stimulation and phaclofen plus a low dose of morphine on the acquisition and expression phases were examined during conditioning sessions and before the test phase, respectively. Results: The conditioning scores were reduced by antagonist injection during the acquisition phase. Interestingly, different intensities exhibited opposite effects on the acquisition phase. Conditioned place preference scores during the acquisition phase were significantly induced by 25 μA electrical stimulation, while conditioning scores were suppressed by electrical stimulation at 150 μA. Phaclofen (2 μg/rat) combined with high intensity induced aversion during the acquisition phase, while inhibiting expression. In contrast, high intensity with phaclofen (1 μg/rat) inhibited only the acquisition session. However, low intensity during the acquisition phase had an additive effect that was prevented by pretreatment with phaclofen (2 μg/rat), but this response was modified by the antagonist's low dose. Conclusions: A behavioral technique called conditioned place preference is frequently used to evaluate learning that is related to rewards. Therefore, lateral habenula electrical stimulation and phaclofen plus morphine could affect place preference through the involvement of the reward system.

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“…The standard 0.4% pilocarpine-induced impaired cellular adherence, perinuclear vesicle accumulation, which heralds cell death, and decreased survival of iHMGEC. Although elusive, pilocarpine-induced MG dropout might be related to its effects on muscarinic acetylcholine receptor 3, present in iHMGEC (Wu et al, 2020).…”

Section: Meibomian Gland Dysfunction (Mgd)mentioning

confidence: 99%

Ocular surface disease: a known yet overlooked side effect of topical glaucoma therapy

et al. 2023

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Ocular surface disease (OSD), a disorder affecting the lacrimal and meibomian glands and the corneal and conjunctival epithelium, is a well-known complication of topical glaucoma therapy. OSD can present as a new or pre-existing condition that virtually any anti-glaucoma formulation can exacerbate. As such, both glaucoma and OSD frequently coexist. Typical OSD symptoms include ocular discomfort, redness, burning, and dryness, whereas signs include periorbital and eyelid skin pigmentation, conjunctival scarring, and superficial punctate keratitis. Pressure-lowering eyedrops can cause toxic, allergic, and inflammatory reactions on the ocular surface. The latter can result from either preservatives or direct toxicity from the active molecule. Although usually mild, OSD can cause significant symptoms that lead to poor quality of life, decreased compliance to therapy, glaucoma progression, and worse visual outcomes. Given the chronic nature of glaucoma, lack of curative therapy, and subsequent lifelong treatment, addressing OSD is necessary. This manuscript aims to provide an up-to-date overview of OSD’s signs, symptoms, and pathogenic mechanisms from glaucoma therapy toxicity.

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M3 but not M4 muscarinic receptors in the rostromedial tegmental nucleus are involved in the acquisition of morphine-induced conditioned place preference

Cited by 8 publications

References 21 publications

The role of NMDA glutamate receptors in the lateral habenula on morphine‐induced conditioned place preference in rats

The role of NMDA glutamate receptors in the lateral habenula on morphine‐induced conditioned place preference in rats

Low Current Intensity Plus an Ineffective Dose of Morphine Affect Conditioning Place Preference Through Different Pathways in the Lateral Habenula

Ocular surface disease: a known yet overlooked side effect of topical glaucoma therapy

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