M518 Role of Intravenous Iron Sucrose Therapy in Moderate to Severe Anaemia in Pregnancy

Kriplani, Alka; Mahey, Reeta; Dash, Biswajit; Kulshrestha, Vidushi; Agarwal, Neha; Bhatla, Neeija

doi:10.1016/s0020-7292(12)61706-8

Cited by 43 publications

(65 citation statements)

References 9 publications

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“…This denotes that the late second trimester Is very vulnerable for anemia of pregnancy. This result is comparable with study of Prasanna B et al, 19 Sunita Dubey, 20 Alka Kriplani et al, 21 Agrawal R, 17 who detected maximum incidence in 26.3±4.07 weeks, 29.68 weeks, 25.69 weeks, 28.2±2.30 weeks and 28.2 weeks respectively. Advancing gestational age significantly increases the risk of anemia due to physiological increase of plasma volume and more requirement of iron for building up of hemoglobin mass at this gestational period.…”

Section: Aims and Objectivesupporting

confidence: 88%

Intravenous Iron Sucrose Therapy in Anemia With Pregnancy

B¹,

Tiwari²,

Sharma³

2015

jemds

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Anemia of pregnancy is most common medical disorder in the developing country, affecting 2 billion population worldwide. In India prevalence is 49.7% of pregnancy contributing to 80% of maternal mortality. Parental iron therapy produces rapid, complete correction of iron deficiency including iron stores. Intravenous iron sucrose therapy has become gold standard in management. It has many advantages over other iron preparations in correction of anemia. AIMS AND OBJECTIVE: Evaluation of hemoglobin improvement, time required, and patient's compliance after iron sucrose therapy. MATERIAL AND METHODS: Retrospective analysis was done of 264 pregnant women with anemia who were admitted in R. D. Gardi Medical College Ujjain M. P. from May 2012 to August 2014, and were diagnosed as iron deficiency anemia and had received intravenous iron sucrose 200 mg weekly till targeted hemoglobin 10gm was reached. RESULTS: majority of women (54.2%) were in age group of 21-29 years. 66.3% were resident of rural area. Anemia was more common (69.7%) in women with vegetarian diet. 83% 0f patients were multigravida. 48.9% cases were of mild, 44.7% of moderate, and 6.4% of severe anemia. There was initial rise in Hb within a week and rise of 1-2gm Hb per week attaining a targeted Hb. CONCLUSION: Iron sucrose is the best tolerated drug, gives mean Hb rise by 600 mg in all grades of anemia and in maximum periods of 4 weeks. Looking at the patient's compliance and feasibility this drug has replaced strategy of unnecessary blood transfusions.

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Section: Aims and Objectivesupporting

confidence: 88%

Intravenous Iron Sucrose Therapy in Anemia With Pregnancy

B¹,

Tiwari²,

Sharma³

2015

jemds

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“…21 Ferritin levels have been noted to rise as early as 2 weeks in an ICMR study conducted by Kriplani et al, where the route of administration was intravenous which has a higher bioavailability than the oral route. 11 Another study conducted by Natsue Koikawa et al amongst Japanese runners, comparing efficacy of lactoferrin and OFS reported a decrease in ferritin stores in both the arms after 8 weeks of therapy. 22 Since there is an inversely proportionally relationship between serum iron concentration (SIC) and TIBC/UIBC hence only a marginal fall was noted amongst these parameters in the OFS arm of our study.…”

Section: Resultsmentioning

confidence: 96%

“…10 The Indian Council of Medical Research (ICMR) has categorized the severity of IDA on the basis of hemoglobin levels as mild, moderate and severe. 11 The treatment modalities available at present, including OFS and parenteral iron, are associated with many ADRs resulting in poor patient compliance and poor response to therapy. 10 Lactoferrin on the other hand is an iron binding glycoprotein which does not produce any ADRs.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study to Evaluate the Efficacy of Oral Lactoferrin Fortified Bovine Colostrum with Oral Iron in the Treatment of Iron Deficiency Anemia

Ramakrishnan¹,

Sivaraman²,

Dutta³

et al. 2018

IJMEDPH

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“…The prevalence of moderate or severe adverse reactions requiring treatment or discontinuation of IV iron was slightly higher in observational studies (13/1352; 9.6 per 1000 women; n = 20 studies) 12,13,19,20,22,23,32,33,40,41,44- [11][12][13][14][15][16]19,20,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][44][45][46][47][49][50][51] or FCM (1/276; 3.6 per 1000).…”

Section: 38mentioning

confidence: 89%

Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: A systematic review

Qassim

Mol

Grivell

et al. 2017

Aust NZ J Obst Gynaeco

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Background: Intravenous (IV) iron in pregnancy is useful where oral iron is not tolerated or a rapid replenishment of iron is required. Aims:To review the literature on the efficacy and safety of different IV iron preparations in the management of antenatal iron-deficiency anaemia (IDA). Materials and methods:We searched MEDLINE, Embase and Scopus from inception to June 2016. Eligible studies were randomised controlled trials (RCTs) and observational studies, involving administration of IV iron (ferric carboxymaltose (FCM), iron polymaltose (IPM) or iron sucrose (IS)), regardless of comparator, to manage antenatal IDA. Two independent reviewers selected studies, extracted data and assessed quality.

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M518 Role of Intravenous Iron Sucrose Therapy in Moderate to Severe Anaemia in Pregnancy

Cited by 43 publications

References 9 publications

Intravenous Iron Sucrose Therapy in Anemia With Pregnancy

Intravenous Iron Sucrose Therapy in Anemia With Pregnancy

A Comparative Study to Evaluate the Efficacy of Oral Lactoferrin Fortified Bovine Colostrum with Oral Iron in the Treatment of Iron Deficiency Anemia

Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: A systematic review

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