M680I/M694V Heterozygous Mutation in Early Onset Familial Mediterranean Fever

Abstract

Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disorder affecting individuals with biallelic pathogenic mutations in the MEFV gene. The disease is characterized by recurrent attacks of fever and serosal inflammation as manifested by abdominal and chest pain. This case report presents an FMF case with a 3-year history of pain crises consisting of severe abdominal pain and fever, lasting up to 72 h. Genetic investigation identified an uncommon heterozygous mutation in the MEFV gene. This mutation is associated with a more severe phenotype of FMF and may lead to an early onset of the disease.

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

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Estimação das características de tráfego em tempo próximo ao real para uso em sistemas de previsão e controle de tráfego.

“…Por A estimação e os estudos de previsão estão relacionados às características do tráfego. Na literatura acadêmica foi possível verificar estudos relativos às principais características: a) velocidade e tempo de percurso (CHEN;CHIEN, 2001;GENTILI;MIRCHANDANI, 2018;HIRIOTAPPA et al, 2017;WANG;MESSMER, 2006) b) densidade (MUIIOZ et al, 2003;QIU et al, 2010;T. DARWISH;K.…”