MA-[D-Leu-4)-OB3, a Small Molecule Synthetic Peptide Leptin Mimetic, Improves Serum Lipid Profiles in Mouse Models of Type 1 and Type 2 Diabetes Mellitus

Hirschstein, Zall; Wang, Anke; Anderson, Brian; Novakovic, Zachary M.; Grasso, Patricia

doi:10.1007/s10989-020-10155-y

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Most recently, the prophylactic capacity of MA-[D-Leu-4]-OB3 to prevent or slow the progression of obesity, insulin resistance, and cognitive impairment in a mouse model of T2DM has been reported (Chua et al, 2021). The ability of MA-[D-Leu-4]-OB3 to improve serum lipid profiles in mouse models of T1DM and T2DM (Hirschstein et al, 2021), suggests an additional application targeted toward reducing the risk of adverse cardiovascular events in humans that are associated with both T1DM and T2DM.…”

Section: Assessing the Effects Of Leptin Mimetics On Cognitive Functionmentioning

confidence: 99%

Harnessing the Power of Leptin: The Biochemical Link Connecting Obesity, Diabetes, and Cognitive Decline

Grasso

2022

Front. Aging Neurosci.

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In this review, the current understanding of leptin’s role in energy balance, glycemic regulation, and cognitive function is examined, and its involvement in maintaining the homeostatic “harmony” of these physiologies is explored. The effects of exercise on circulating leptin levels are summarized, and the results of clinical application of leptin to metabolic disease and neurologic dysfunction are reviewed. Finally, pre-clinical evidence is presented which suggests that synthetic peptide leptin mimetics may be useful in resolving not only the leptin resistance associated with common obesity and other elements of metabolic syndrome, but also the peripheral insulin resistance characterizing type 2 diabetes mellitus, and the central insulin resistance associated with certain neurologic deficits in humans.

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Section: Assessing the Effects Of Leptin Mimetics On Cognitive Functionmentioning

confidence: 99%

Harnessing the Power of Leptin: The Biochemical Link Connecting Obesity, Diabetes, and Cognitive Decline

Grasso

2022

Front. Aging Neurosci.

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Prophylactic Application of MA-[d-Leu-4]-OB3, a Small Molecule Synthetic Peptide Leptin Mimetic, Prevents or Slows the Progression of Obesity, Insulin Resistance, and Cognitive Impairment in a Mouse Model of Type 2 Diabetes Mellitus

Chua

Novakovic

Grasso

2021

Int J Pept Res Ther

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MA-[D-Leu-4)-OB3, a Small Molecule Synthetic Peptide Leptin Mimetic, Improves Serum Lipid Profiles in Mouse Models of Type 1 and Type 2 Diabetes Mellitus

Cited by 2 publications

References 22 publications

Harnessing the Power of Leptin: The Biochemical Link Connecting Obesity, Diabetes, and Cognitive Decline

Harnessing the Power of Leptin: The Biochemical Link Connecting Obesity, Diabetes, and Cognitive Decline

Prophylactic Application of MA-[d-Leu-4]-OB3, a Small Molecule Synthetic Peptide Leptin Mimetic, Prevents or Slows the Progression of Obesity, Insulin Resistance, and Cognitive Impairment in a Mouse Model of Type 2 Diabetes Mellitus

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