MAC3A and MAC3B, Two Core Subunits of the MOS4-Associated Complex, Positively Influence miRNA Biogenesis

Li, Shengjun; Liu, Kan; Zhou, Bangjun; Li, Mu; Zhang, Shuxin; Zeng, Lirong; Zhang, Chi; Yu, Bin

doi:10.1105/tpc.17.00953

Cited by 69 publications

(84 citation statements)

References 72 publications

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“…Therefore, our data suggest that SKIP regulates the floral transition through the transcriptional regulation of FLC via an interaction with the ELF7, and mediates circadian clock function and abiotic stress responses through the regulation of pre-mRNA splicing by interacting with MAC3A/MAC3B. Pleiotropic Regulatory Locus 1 and STIPL1 are both components of the spliceosome; the former is required for responses of sucrose and stress and biogenesis of miRNAs, and the latter is required for proper control of the circadian clock in Arabidopsis (N emeth et al, 1998;Jones et al, 2012;Li et al, 2018). In comparison, VIP4 is a Paf1c component and is required for flowering time control in Arabidopsis (Zhang & van Nocker, 2002).…”

Section: Discussionmentioning

confidence: 83%

“…Pleiotropic Regulatory Locus 1 and STIPL1 are both components of the spliceosome; the former is required for responses of sucrose and stress and biogenesis of miRNAs, and the latter is required for proper control of the circadian clock in Arabidopsis (Németh et al ., ; Jones et al ., ; Li et al ., ). In comparison, VIP4 is a Paf1c component and is required for flowering time control in Arabidopsis (Zhang & van Nocker, ).…”

Section: Discussionmentioning

confidence: 97%

“…The double mutant of the two knockout alleles (mac3a-2 mac3b-2) was embryonic lethal, while double mutants for mac3a-1 mac3b-1, mac3a-1 mac3b-2, and mac3a-2 mac3b-1 were viable but smaller than wild-type plants ( Fig. S2d; Monaghan et al, 2009;Li et al, 2018). Among them, mac3a-1 mac3b-1 and mac3a-2 mac3b-1 were similar, but weaker, than mac3a-1 mac3b-2 ( Fig.…”

Section: Skip and Mac3a/mac3b Are In The Same Complexmentioning

confidence: 99%

“…MAC3A and MAC3B are homologous proteins that were first identified as components of the Modifier Of snc1 4 (MOS4)-associated complex, which is required for the alternative splicing of resistance (R) genes and which is involved in the regulation of innate immunity and defense responses in Arabidopsis (Palma et al, 2007;Monaghan et al, 2009), and modulates miRNA biogenesis through mediating the transcription, processing, and stability of pre-miRNA (Li et al, 2018). In the present study, we found that SKIP interacts with MAC3A/MAC3B and two other splicing factors (Pleiotropic Regulatory Locus 1 (PRL1), Spliceosomal Timekeeper Locus1 (STIPL1)) in the spliceosome to mediate pre-mRNA splicing and maintain responsiveness to environmental changes in Arabidopsis.…”

Section: Introductionmentioning

confidence: 99%

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SKIP regulates environmental fitness and floral transition by forming two distinct complexes in Arabidopsis

Yang

Shang

et al. 2019

New Phytologist

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Summary Ski‐interacting protein (SKIP) is a bifunctional regulator of gene expression that works as a splicing factor as part of the spliceosome and as a transcriptional activator by interacting with EARLY FLOWERING 7 (ELF7). MOS4‐Associated Complex 3A (MAC3A) and MAC3B interact physically and genetically with SKIP, mediate the alternative splicing of c. 50% of the expressed genes in the Arabidopsis genome, and are required for the splicing of a similar set of genes to that of SKIP. SKIP interacts physically and genetically with splicing factors and Polymerase‐Associated Factor 1 complex (Paf1c) components. However, these splicing factors do not interact either physically or genetically with Paf1c components. The SKIP‐spliceosome complex mediates circadian clock function and abiotic stress responses by controlling the alternative splicing of pre‐mRNAs encoded by clock‐ and stress tolerance‐related genes. The SKIP‐Paf1c complex regulates the floral transition by activating FLOWERING LOCUS C (FLC) transcription. Our data reveal that SKIP regulates floral transition and environmental fitness via its incorporation into two distinct complexes that regulate gene expression transcriptionally and post‐transcriptionally, respectively. It will be interesting to discover in future studies whether SKIP is required for integration of environmental fitness and growth by control of the incorporation of SKIP into spliceosome or Paf1c in plants.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 97%

Section: Skip and Mac3a/mac3b Are In The Same Complexmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

SKIP regulates environmental fitness and floral transition by forming two distinct complexes in Arabidopsis

Yang

Shang

et al. 2019

New Phytologist

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“…Being able to interact with both Pol II and DCL1, the Elongator complex might facilitate the establishment of a processing complex during transcription (Fang et al ., 2015a). Similar functions have been attributed to components of the MOS4‐associated complex (Zhang et al ., , 2014a; Jia et al ., ; Li et al ., ), a general factor that associates with the spliceosome and is conserved in plants and animals (Koncz et al ., ). After these initial events of transcription and recruitment of factors to the nascent primary transcript, the miRNA processing machinery needs to cut the stem‐loop precursor to release the small RNA.…”

Section: Microrna Processing In Plantsmentioning

confidence: 99%

Keep calm and carry on: miRNA biogenesis under stress

2019

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Summary MicroRNAs (miRNAs) are major post‐transcriptional regulators of gene expression. Their biogenesis relies on the cleavage of longer precursors by a nuclear localized processing machinery. The evolutionary preference of plant miRNAs to silence transcription factors turned these small molecules into key actors during growth and adaptive responses. Furthermore, during their life cycle plants are subject to changes in the environmental conditions surrounding them. In order to face these changes, plants display unique adaptive capacities based on an enormous developmental plasticity, where miRNAs play central roles. Many individual miRNAs have been shown to modulate the plant response to different environmental cues and stresses. In the last few years, increasing evidence has shown that not only individual genes encoding miRNAs but also the miRNA pathway as a whole is subject to regulation in response to external stimulus. In this review, we discuss the current knowledge about the miRNA pathway. We dissect the pathway to analyze the events leading to the generation of these small RNAs and emphasize the regulation of core components of the miRNA biogenesis machinery.

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Alternative splicing: An efficient regulatory approach towards plant developmental plasticity

Sajid

Zhou

et al. 2022

WIREs RNA

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Alternative splicing (AS) is a gene regulatory mechanism that plants adapt to modulate gene expression (GE) in multiple ways. AS generates alternative isoforms of the same gene following various development and environmental stimuli, increasing transcriptome plasticity and proteome complexity. AS controls the expression levels of certain genes and regulates GE networks that shape plant adaptations through nonsense-mediated decay (NMD). This review intends to discuss AS modulation, from interaction with noncoding RNAs to the established roles of splicing factors (SFs) in response to endogenous and exogenous cues. We aim to gather such studies that highlight the magnitude and impact of AS, which are not always clear from individual articles, when AS is increasing in individual genes and at a global level. This work also anticipates making plant researchers know that AS is likely to occur in their investigations and that dynamic changes in AS and their effects must be frequently considered. We also review our understanding of AS-mediated posttranscriptional modulation of plant stress tolerance and discuss its potential application in crop improvement in the future.

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MAC3A and MAC3B, Two Core Subunits of the MOS4-Associated Complex, Positively Influence miRNA Biogenesis

Cited by 69 publications

References 72 publications

SKIP regulates environmental fitness and floral transition by forming two distinct complexes in Arabidopsis

SKIP regulates environmental fitness and floral transition by forming two distinct complexes in Arabidopsis

Keep calm and carry on: miRNA biogenesis under stress

Alternative splicing: An efficient regulatory approach towards plant developmental plasticity

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