2015
DOI: 10.1016/j.bios.2015.04.052
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Mach–Zehnder interferometer (MZI) point-of-care system for rapid multiplexed detection of microRNAs in human urine specimens

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Cited by 65 publications
(42 citation statements)
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“…Less frequent, upregulation of certain let-7 family members has also been observed, suggesting that let-7 does not play a tumour suppressor function under all circumstances and in all tissues ( 6 ). Higher levels of let-7 miRNAs in urine has been reported in bladder cancer ( 7 ). There are no data about urinary let-7 miRNAs in RCC, but increased urinary levels of some of the let-7 family members were found in patients with autosomal dominant polycystic kidney disease suggesting their abundance in urine and therefore also potential utility in other renal diseases such as cancer ( 8 ).…”
Section: Introductionmentioning
confidence: 90%
“…Less frequent, upregulation of certain let-7 family members has also been observed, suggesting that let-7 does not play a tumour suppressor function under all circumstances and in all tissues ( 6 ). Higher levels of let-7 miRNAs in urine has been reported in bladder cancer ( 7 ). There are no data about urinary let-7 miRNAs in RCC, but increased urinary levels of some of the let-7 family members were found in patients with autosomal dominant polycystic kidney disease suggesting their abundance in urine and therefore also potential utility in other renal diseases such as cancer ( 8 ).…”
Section: Introductionmentioning
confidence: 90%
“…In addition to established label free detection modalities, such as conventional Kretschmann geometry surface plasmon resonance 84 , other sensing mechanisms have been explored for applications in miRNA analysis, including nano-particle scattering on flexible silicon substrates, 85 surface enhanced Raman spectroscopy, 86 functionalized gold nanoprisims attached to silanized glass, 87 Mach-Zehender interferometers, 88 and total internal fluorescence microscopy. 89 An impressive gold nanowire plasmonic based detection mechanism was developed as a microfluidic lateral flow assay.…”
Section: Biosensor Methodsmentioning
confidence: 99%
“…Hofmann et al [84] proposed a double-stranded ligation assay that yields results in 30 min. Liu et al [85] presented a Mach-Zehnder interferometer-based approach with an even shorter turnaround time of 15 min. Labib and Berezovski [86] reviewed electrochemical-based detection strategies.…”
Section: New Measurement Devicesmentioning
confidence: 98%