Machado-Joseph Disease / Spinocerebellar Ataxia Type 3

Nóbrega, Clévio; Almeida, Luís Pereira de

doi:10.5772/28576

Cited by 2 publications

(2 citation statements)

References 244 publications

(263 reference statements)

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“…For Experiment 2, three marmosets (three males, aged 184 ± 1.4 days) were recruited from the polyglutamine disease model transgenic marmoset line (second generation) recently established in our laboratory (Tomioka et al, 2017). Polyglutamine diseases are heritable neurodegenerative disorders caused by expansion of trinucleotide repeats for the polyglutamine tract (Nóbrega and De Almeida, 2012). This animal model typically shows a variety of motor disease symptoms characterized by progressively lower daily activity (Tomioka et al, 2017).…”

Section: Animalsmentioning

confidence: 99%

“…Motility declines following functional deterioration of multiple body parts (Ferrucci et al, 2016;Buchman et al, 2018). Movement disorder often accompanies certain neurologic diseases (Taroni and Didonato, 2004;Nóbrega and De Almeida, 2012), severely limiting an individual's viability (Barlow et al, 1996;Robinson et al, 2013). Behavioral phenotyping of experimental animal models of human disease aims to quantitatively characterize the motor behavior and its disease-specific deviation from healthy animals (Lin et al, 2001;Pratte et al, 2011;Urbach et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Motility Profile of Captive-Bred Marmosets Revealed by a Long-Term In-Cage Monitoring System

Koizumi

Nogami

Owari

et al. 2021

Front. Syst. Neurosci.

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A quantitative evaluation of motility is crucial for studies employing experimental animals. Here, we describe the development of an in-cage motility monitoring method for new world monkeys using off-the-shelf components, and demonstrate its capability for long-term operation (e.g., a year). Based on this novel system, we characterized the motility of the common marmoset over different time scales (seconds, hours, days, and weeks). Monitoring of seven young animals belonging to two different age groups (sub-adult and young-adult) over a 231-day period revealed: (1) strictly diurnal activity (97.3% of movement during daytime), (2) short-cycle (∼20 s) transition in activity, and (3) bimodal diurnal activity including a “siesta” break. Additionally, while the mean duration of short-cycle activity, net daily activity, and diurnal activity changed over the course of development, 24-h periodicity remained constant. Finally, the method allowed for detection of progressive motility deterioration in a transgenic marmoset. Motility measurement offers a convenient way to characterize developmental and pathological changes in animals, as well as an economical and labor-free means for long-term evaluation in a wide range of basic and translational studies.

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Section: Animalsmentioning

confidence: 99%