Machaerium hirtum (Vell.) Stellfeld Alleviates Acute Pain and Inflammation: Potential Mechanisms of Action

Lopes, Juliana Agostinho; Rodrigues, Vinícius Peixoto; Tangerina, Marcelo Marucci Pereira; Rocha, Lúcia Regina Machado da; Nishijima, Catarine Massucato; Nunes, Vânia Vasti Alfieri; Almeida, Luiz Fernando Rolim de; Vilegas, Wagner; Santos, Adair R.S.; Sannomiya, Míriam; Hiruma-Lima, Clélia Akiko

doi:10.3390/biom10040590

Cited by 10 publications

(5 citation statements)

References 66 publications

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“…Quinic Acid ( 2 H-H2O] -. These findings suggest the presence of quinic acid (Gouveia & Castilho, 2011), previously detected in other Machaerium species (Tahira, 2022;Sannomiya et al, 2020;Lopes et al, 2020).…”

Section: Organic Acids Identificationsupporting

confidence: 78%

Exploring antifungal potential: The flavonoid composition of Machaerium villosum extracts against Cryptococcus neoformans

Dourado,

Kamikawachi,

Ferreira

et al. 2024

RSD

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The escalating prevalence of fungal infections, coupled with the limitations and adverse effects associated with existing antifungal drugs, necessitates the exploration of alternative therapeutic approaches. The objective of this study was, therefore, to conduct a chemical analysis and assess the biological potential of the hydroethanolic extract obtained from the leaves of Machaerium villosum. Thus, this study investigates the extract from this plant, which belongs to the Fabaceae family, known for its rich flavonoid content. Employing UHPLC-ESI-IT-MS/MS, the extract was characterized, revealing the presence of various flavonoids, including glycosylated derivatives of kaempferol and quercetin, along with organic acids and fatty acid derivatives. The total flavonoid content was quantified at 45.7 mg/g. Subsequent antifungal evaluation unveiled significant activity against Cryptococcus neoformans, with a minimum inhibitory concentration (MIC) of 16 μg/ml and fungicidal action at 256 μg/ml. The observed efficacy against C. neoformans aligns with the documented antifungal properties of flavonoids, which disrupt membrane integrity and impede crucial cellular processes. The findings suggest that M. villosum extract, particularly its flavonoid constituents, holds promise as a potential source for developing new antifungal therapies.

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Section: Organic Acids Identificationsupporting

confidence: 78%

Exploring antifungal potential: The flavonoid composition of Machaerium villosum extracts against Cryptococcus neoformans

Dourado,

Kamikawachi,

Ferreira

et al. 2024

RSD

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“…9), was also another species of Papilionoideae studied. It is a small tree with moderately heavy wood, resistant, elastic and widely used in urban and rural afforestation because of its excellent shade (Lopes et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Dendrological characteristics of tree species of the Papilionoideae subfamily in a cerrado sensu stricto physiognomy, Tocantins, Brazil

Dias,

De Souza,

Trinetto

et al. 2024

OLEL

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The Cerrado harbors 5% of the entire biological diversity of the planet, and also presents about 11 phytophysiognomies which vary from forest formations to country and savanna compositions, according to their aspect and composition. In view of the great diversity of species in the Fabaceae family and the consequent difficulty in recognizing them, more studies are needed to contribute to the correct identification of species, aiming toward better presentation of the collected data. The present work aims to elaborate/create a key for dendrological identification of some tree species of the Papilionoideae subfamily. The work was developed at the Federal University of Tocantins, campus of Gurupi, TO, Brazil. The identification key was elaborated based on the dendrological and morphological descriptions identified in the sampled species, namely: habit, trunk morphology, aspects of the bark (rhytidome and dehiscence), leaves (type, phyllotaxis, characteristics of the petiole, presence and type of stipule, nervation, color, characterization of the rachis, presence of glands, margin of the limb, scars), presence or absence of other characteristics (latex and other exudation, lenticels, thorns or aculeles). The dendrological identification key provided better visualization of the collected data, enabling quick and easy identification of the plant species sampled.

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“…The mice were divided into three groups. The inflammatory process was induced topically by applying xylol to the left ear [45]. After 25 min of xylol application, one group (n = 6) was treated with PBS (positive control), whereas a second group was treated with PRA-NLC (n = 6).…”

Section: Xylol-induced Inflammation Model In Mouse Earmentioning

confidence: 99%

A Novel Approach for Dermal Application of Pranoprofen-Loaded Lipid Nanoparticles for the Treatment of Post-Tattoo Inflammatory Reactions

De Grau-Bassal,

Mallandrich,

Sosa

et al. 2024

Pharmaceutics

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Recently, the number of people acquiring tattoos has increased, with tattoos gaining significant popularity in people between 20 and 40 years old. Inflammation is a common reaction associated with tattooing. The purpose of this study was to evaluate a nanostructured lipid carrier loading pranoprofen (PRA-NLC) as a tattoo aftercare formulation to reduce the inflammation associated with tattooing. In this context, the in vitro drug release and the ex vivo permeation-through-human-skin tests using Franz cells were appraised. The tolerance of our formulation on the skin was evaluated by studying the skin’s biomechanical properties. In addition, an in vivo anti-inflammatory study was conducted on mice skin to evaluate the efficacy of the formulation applied topically after tattooing the animals. PRA-NLC showed a sustained release up to 72 h, and the amount of pranoprofen retained in the skin was found to be 33.48 µg/g/cm2. The formulation proved to be well tolerated; it increased stratum corneum hydration, and no signs of skin irritation were observed. Furthermore, it was demonstrated to be non-cytotoxic since the cell viability was greater than 80%. Based on these results, we concluded that PRA-NLC represents a suitable drug delivery carrier for the transdermal delivery of pranoprofen to alleviate the local skin inflammation associated with tattooing.

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Machaerium hirtum (Vell.) Stellfeld Alleviates Acute Pain and Inflammation: Potential Mechanisms of Action

Cited by 10 publications

References 66 publications

Exploring antifungal potential: The flavonoid composition of Machaerium villosum extracts against Cryptococcus neoformans

Exploring antifungal potential: The flavonoid composition of Machaerium villosum extracts against Cryptococcus neoformans

Dendrological characteristics of tree species of the Papilionoideae subfamily in a cerrado sensu stricto physiognomy, Tocantins, Brazil

A Novel Approach for Dermal Application of Pranoprofen-Loaded Lipid Nanoparticles for the Treatment of Post-Tattoo Inflammatory Reactions

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