Machilin G and Four Neolignans from Young Fruits ofMagnolia denudataShow Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production

Abstract

Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-activated-murine macrophage cell line, J774.1. Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.

Biomimetic Total Synthesis and the Biological Evaluation of Natural Product (−)-Fargesone A as a Novel FXR Agonist

“…Natural products are one of the primary sources of drug molecules; many approved drugs are derived from natural products and their secondary derivatives. , Fargesone A (FA) is a natural product isolated from the flower buds of Magnolia fargesii that has been used in traditional Chinese medicine, named Xin Yi . Sporadic studies reported that FA showed weak Ca 2+ antagonistic and anti-inflammatory activities. , However, the poor accessibility from natural product isolation (68 mg out of 12.7 kg dried leaves) significantly hinders its more extensive biological evaluations in vitro and in vivo. Here, through a high-throughput chemical screening of a natural product library and follow-up biological validations, we have identified FA as a potent and selective FXR novel agonist (Figure A).…”

In Vitro Evaluation on the Antiobesity Effect of Lignans from the Flower Buds of Magnolia denudata

“…Magnolia species have a disjunct distribution in east and southeastern Asia, northeastern and central America, and west Indies, and some species grow in South America. Several kinds of Magnolia species, such as Magnolia salicifolia, Magnolia kobus, and Magnolia denudata, have reportedly been used for centuries as folk medicines in Asian countries . Their dried flower buds are sources of crude drugs.…”

“…denudata is a small deciduous tree that typically grows to 30–40 ft with a rounded spreading crown. It contains many kinds of lignans and neolignans. − Many studies have focused on its interesting biological activities, such as antiplatelet activation, cholesterol acetyltransferase and melanogenesis inhibitions, anti-inflammation, antiallergy, and apoptosis induction. ,− However, there is currently still insufficient evidence on the antiobesity effect of M. denudata and its components.…”

“…Several kinds of Magnolia species, such as Magnolia salicifolia, Magnolia kobus, and Magnolia denudata, have reportedly been used for centuries as folk medicines in Asian countries. 1 Their dried flower buds are sources of crude drugs. For example, the dried flower buds of M. denudata have been known as Xin Yi in traditional Chinese herbal medicine and are used to treat emphyema, nasal congestion, sinusitis, and allergic or chronic rhinitis.…”

Neolignan Derivatives from the Flower of Magnolia biondii Pamp. and their Effects on IL-2 expression in T-cells

“…Furthermore, denudatin B reported to have inhibitory effects on NO production through the decreased expression of the iNOS gene 21 and free radical scavenging activity…”