Recent burgeoning development in nanotechnology unfold an avenue in the manufacturing industry. Owing to the superior heat transfer potential of nanoadditives mentioned recently, it could be interesting to improve the heat transfer and tribological capability of metal cutting fluids by mixing nanofluids in emulsions properly. In order to attain high-performance cutting of difficult-to-cut alloys, hybrid nanofluids assisted Minimum Quantity Lubrication (MQL) system is applied with the anticipation of efficient lubrication and heat transfer. Taguchi based L16(43) orthogonal array is used involving nanofluids concentrations of alumina-multiwalled carbon nanotubes (Al2O3-MWCNTs) air pressure and cooling flow rate at constant cutting conditions in the milling of Ti-6Al-4V. The resultant cutting force (FR), cutting temperature (T), and surface roughness (Ra) is considered as key machining responses. Besides, tool wear, chip analysis, and surface topography are also analyzed under the effect of hybrid nanofluids. Findings have shown the minimum resultant force, cutting temperature and surface roughness of 24.3N, 148.7oC, and 0.67µm respectively at nanofluids concentration of 0.24vol%, 120ml/h of flow rate at 0.6MPa of air pressure. The microscopic analysis of the end-mill depicted minor thermal damage, chip-welding, and coating peeling. Also, chip analysis depicts the clean back surface and less melting of saw-tooth chip edges. The surface topography confirms the less micro-adhesion of chips and material debris. The summary showed that appropriately chosen MQL parameters have improved the lubrication/cooling performance by providing oil film and enhancing the milling performance measures. The outcomes of the proposed study are useful for the manufacturing industry for the enhancement of process performance.