Magnesium oxide-reinforced wood fiber composites (MgO/WF) are a new type of multifunctional material, which can be used in different occasions, such as shopping malls, hotels, and residential buildings. Referring to the relevant literature, there is no research on the milling performance of MgO/WF. In order to better understand the relevant knowledge of the processability of MgO/WF, three cutters with different helix angles were used in this experiment to carry out the cutting of MgO/WF, and the variation trend of its cutting force, tool wear, and surface roughness was measured. The results are as follows: First, under the same cutting parameters, the resultant force decreases with the increase of helix angle. Second, with the increase of helix angle, the tool wear was slightly improved. Third, the surface roughness (Ra) showed an increasing trend with the decrease of helix angle. In the end, when milling MgO/WF, better machined surface quality and less tool wear can be obtained by selecting the tool with larger helix angle.