2022
DOI: 10.1038/s12276-022-00846-5
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Machine-learning algorithms for asthma, COPD, and lung cancer risk assessment using circulating microbial extracellular vesicle data and their application to assess dietary effects

Abstract: Although mounting evidence suggests that the microbiome has a tremendous influence on intractable disease, the relationship between circulating microbial extracellular vesicles (EVs) and respiratory disease remains unexplored. Here, we developed predictive diagnostic models for COPD, asthma, and lung cancer by applying machine learning to microbial EV metagenomes isolated from patient serum and coded by their accumulated taxonomic hierarchy. All models demonstrated high predictive strength with mean AUC values… Show more

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Cited by 9 publications
(3 citation statements)
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“…While CT can provide detailed structural information with its high-resolution 3D imaging capabilities, other data, such as PFT, 39 clinical data, 40,41 chest x-ray, 42 and magnetic resonance imaging (MRI), 43 can also provide useful information. PFT is noninvasive, and allows for longitudinal tracking of lung function, but is limited to characterizing anatomical changes.…”
Section: Single-modality Versus Multimodalitymentioning
confidence: 99%
“…While CT can provide detailed structural information with its high-resolution 3D imaging capabilities, other data, such as PFT, 39 clinical data, 40,41 chest x-ray, 42 and magnetic resonance imaging (MRI), 43 can also provide useful information. PFT is noninvasive, and allows for longitudinal tracking of lung function, but is limited to characterizing anatomical changes.…”
Section: Single-modality Versus Multimodalitymentioning
confidence: 99%
“…Benefiting from the rapid advancement of medical technology, many studies have been able to use OTU data for analysis [7,20]. Pasolli et al [22] comprehensively evaluated the prediction tasks based on shotgun metagenomics and the method of microbial phenotype association evaluation, mainly using support vector machines and random forest models to predict diseases, and with the help of Lasso and elastic net (ENet) Regularized Multiple Logistic Regression.…”
Section: Related Workmentioning
confidence: 99%
“…AI techniques range in complexity from machine learning (ML) algorithms to deep learning (DL). While simple models have been used since the 1960s in the form of logistic regression, recent decades have seen the development of sophisticated neural network algorithms to predict risk for breast, lung, and other cancers [20][21][22][23][24][25][26][27]. The area under the curve (AUC) is a commonly used metric in risk modeling.…”
Section: Artificial Intelligencementioning
confidence: 99%