Machine Learning-Based Clinical Decision Support System for Automatic Diagnosis of COVID-19 based on Clinical Data

Abstract

Introduction: Needless to say that correct and real-time detection and effective prognosis of the COVID-19 are necessary to deliver the best possible care for patients and, accordingly, diminish the pressure on the healthcare industries. Hence our paper aims to present an intelligent algorithm for selecting the best features from the dataset and developing Machine Learning(ML) based models to predict the COVID-19 and finally opted for the best-performing algorithm.
 Methods: In this developmental study, the clinical data of 1703 COVID-19 and non-COVID-19 patients Using a single-center registry from February 9, 2020, to December 20, 2020, were used. The Minimum Redundancy Maximum Relevance (mRMR) feature selection algorithm identified the most relevant variables. Then, chosen features feed into the several data mining methods, including K-Nearest Neighbors, AdaBoost Classifier, Decision Tree, HistGradient Boosting Classifier, and Support Vector Machine. A 10-fold cross-validation method and six performance evaluation metrics were used to evaluate and compare these implemented algorithms, and finally, the best model was implemented.
 Results: Out of the 34 included features, 11 variables were selected as the essential features. The results of using ML algorithms indicated that the best performance belongs to the AdaBoost classifier with mean accuracy = 92.9%, mean specificity = 89.3%, mean sensitivity = 94.2%, mean F-measure = 91.6 %, mean KAPA = 94.3% and mean ROC = 92.1 %.
 Conclusion: The empirical results reveal that the Adaboost model yielded higher performance than other classification models and developed our Clinical Decision Support Systems (CDSS) interface to discriminate positive COVID-19 from negative cases.

Clinical decision support systems (CDSS) in assistance to COVID‐19 diagnosis: A scoping review on types and evaluation methods

“…These studies also recommended the use of CDSS in future research. Finally, 68 articles met all the inclusion criteria 5,17,34–99 . The flowchart of the selection process is shown in Figure 1.…”

“…Types of CDSS to assist in diagnosing COVID‐19 are shown in Figure 4. Most of the studies used ICDSS based on ML (nonknowledge‐based CDSS) ( n = 52 [76.5%]) 34–85 . In these studies, the most common methods for designing CDSS were CNN ( n = 33), 38,40–42,45–47,49–52,54,56–69,71,72,78,82–85 SVM ( n = 8), 35,36,39,43,44,54,56,57 RF ( n = 7), 34,35,37,39,42,44,55 and KNN ( n = 7) 36,37,39,42,43,55,56 (Table 1 and Appendix ).…”

“…In these studies, the most common methods for designing CDSS were CNN ( n = 33), 38,40–42,45–47,49–52,54,56–69,71,72,78,82–85 SVM ( n = 8), 35,36,39,43,44,54,56,57 RF ( n = 7), 34,35,37,39,42,44,55 and KNN ( n = 7) 36,37,39,42,43,55,56 (Table 1 and Appendix ). Some studies used a combination of ML methods to develop CDSS ( n = 14) 34–37,39,42–44,53,55–57,70,84 (Appendix ). Rule sets ( n = 8), 5,17,88,89,93,94,96,97 fuzzy mathematical models (n = 5), 86,90–92,95 and ontology ( n = 3) 87,98,99 were used for developing ICDSS based on ES (knowledge‐based CDSS), respectively (Appendix ).…”

“…Most studies used a combination of performance metrics to evaluate CDSS ( n = 40) (Appendix ). In most of these studies, accuracy ( n = 43), 35–40,42–47,49–69,71,72,76–78,80–83,85 sensitivity (recall) ( n = 35) 35–37,39,41–44,46,47,49–54,56,57,61,63–69,71,72,76,78,81–85 and F1‐score ( n = 26) 34–36,39,41–43,46,47,50,52–54,56,57,60,61,63,64,66,68,69,81,82,84,85 were used (Table 2). Other metrics for evaluating ICDSS based on ML were the Matthews correlation coefficient (MCC), 52,56,58 receiver operating characteristic (ROC) curve, 34,36,70 and so on (Appendix ).…”

Predicting Risk of Mortality in COVID-19 Hospitalized Patients using Hybrid Machine Learning Algorithms

“…Thus, ML-based prediction models can significantly contribute to triaging hazardous patients and allocating the limited hospital resources for mortality risk prediction [72,73], resulting in reducing uncertainty by quantitative, objective, and evidence-based models for risk classification. Furthermore, the ML provides a better strategy for physicians to reduce complications and improve patient survival [74][75][76][77].…”