“…Persistent lack of physical comprehension continuously stymies preferable prediction performance of the key parameters in multiphase flow and reactor systems, although scientists have made systematic contributions to experimentally formulated correlations throughout the past decades. − The correlations of the key parameters in multiphase units are commonly expressed by gas/liquid/solid phase properties, operating conditions (e.g., phase concentration, velocity, and temperature), devices configurations (e.g., height and diameter), or a combination of them in dimensionless forms such as Archimedes, Froude, Nusselt, Reynolds, Sherwood, and Weber numbers. However, the prediction discrepancies between the existing empirical correlations of key parameters such as the particle entrainment and minimum fluidization velocity in gas-particle riser flows can reach several orders of magnitude. , Fortunately, the advanced research and development of flexible ML tools have the potential to complement the incomplete knowledge to boost the prediction ability of key multiphase field parameters such as mass flow rate/flux, − minimum fluidization velocity, , mixing rate/index, , overall/local hold-up, − pressure/pressure drop, − velocity, ,− temperature, − and other parameters − in multiphase/particulate flows and reactors. Note that interested readers may be referred to a relatively comprehensive list of the existing literature summarized in Table S4.…”