Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy

Lötsch, Jörn; Sipilä, Reetta; Tasmuth, Tiina; Kringel, Dario; Estlander, Ann-Mari; Meretoja, Tuomo J.; Kalso, Eija; Ultsch, Alfred

doi:10.1007/s10549-018-4841-8

Cited by 61 publications

(50 citation statements)

References 57 publications

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“…Patients with a Ki-67 expression of 14-20% contributed approximately half of the subjects (n=13), which was double of the subjects with Ki-67 expression of <14% (n=6) and >20% (n=6). The majority of the tumor sizes before chemotherapy were found between 101-300 cm 3 which is the medium category for tumor size and about one-third of the subjects had a tumor size of more than 300 cm 3 .…”

Section: Resultsmentioning

confidence: 97%

“…Neoadjuvant chemotherapy is defined as the administration of systemic drugs before doing surgical intervention that is also the standard treatment to treat locally advanced breast cancer as well as a standard option for primary operable disease. 3 Ki-67 is a protein strictly associated with proliferation of the cell. Since the discovery of this protein, it has been widely introduced to be a proliferation marker for tumor cells.…”

Section: Introductionmentioning

confidence: 99%

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Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung

Rezano¹,

Pan²,

Istiqomah³

et al. 2018

IJIHS

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Objective: To analyze the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer. Methods:A retrospective observational study on the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer was conducted. This study included twenty-five female patients with invasive breast cancer who met the inclusion criteria. Parameters analyzed were age, tumor size, and immunohistochemical expression of Ki-67. Size of the tumor at pre-and post-neoadjuvant chemotherapy were obtained in cm 3 and compared between 3 groups of Ki-67 expression levels. One way ANOVA was used to perform the statistical analysis.Results: A significant difference in changes of tumor size for Ki-67 level >20% compared to <14% and 14-20% was seen. Based on the result, neoadjuvant chemotherapy was proven to have similar effects in patients with Ki-67 expression of <14% and 14-20% but less effective in patients with Ki-67 expression of >20%. Conclusions:Low to modest expression of Ki-67 was a better biomarker to predict the response of neoadjuvant chemotherapy in patients with invasive breast cancer compared to high expression of Ki-67. However, the cut-off value of 20% could be ideal to predict the outcome of neoadjuvant chemotherapy in patients with invasive breast cancer.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung

Rezano¹,

Pan²,

Istiqomah³

et al. 2018

IJIHS

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“…Anger‐in is thought to be associated with generalized negative affect, which would also mediate its influence on pain and especially on coping behavior . In a previous study in which we used a machine‐learning approach to identify factors that associate with persistent pain after breast cancer surgery, we found that higher anger‐in was associated with pain intensity at 3 years after surgery …”

Section: Introductionmentioning

confidence: 91%

“…Research suggests that there is an association between anger regulation and both acute and chronic pain . Compared with anger‐in, anger‐out has been reported to have a more independent effect on pain .…”

Section: Introductionmentioning

confidence: 99%

The relationship between anger regulation, mood, pain, and pain‐related disability in women treated for breast cancer

et al. 2019

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Objective: Anger, depressive symptoms, and anxiety are known reactions to cancer and suggested to modulate pain experience. We examined the association between anger regulation, mood, and pain in 952 breast cancer patients followed for 3 years.Methods: Preoperatively, the patients completed questionnaires about depressive symptoms (BDI), state anxiety (STAI), anger regulation (STAXI-2), and pains in the surgical and other areas. Experimental pain sensitivity was tested. In the follow-up, BDI and STAI were assessed at 1 and at 6 months and at 1, 2, and 3 years after surgery.Pain in the surgical area was evaluated during the first 7 days and at 1 and 3 years after surgery. Pain-related disability was assessed at 3 years after surgery. Latent profile analyses were performed to identify mood profiles, and regression analyses to find independent predictors for mood and pain variables.Results: Anger inhibition and pain had associations with ongoing depressive symptoms and anxiety. Pain-related disability was associated with high anxiety at a hazard ratio (HR) of 2.24 (95% CI, 1.17-4.27), with older age (HR 1.07, 95% CI, 1.01-1.13), and with pain in the surgical area (HR 3.04, 95% CI, 2.41-3.85), but not with anger variables. Any relationship between anger regulation and pain intensity disappeared after controlling for age and mood.Conclusions: Different forms of pain are important to recognize and treat to support breast cancer patients' psychological well-being. Anger inhibition could be a target for psychotherapeutic intervention, to help with ongoing mood symptoms. The relationship between anger regulation and pain is not straightforward. KEYWORDS anger regulation, breast cancer, depressive symptoms, oncology, pain, pain-related disability, state anxiety 1 | BACKGROUND The quality of life of cancer survivors has become an important issue as improvements in cancer treatments have increased the survival rates. 1 Both depression and anxiety are well-recognized reactions to a breast cancer diagnosis. 2 Feelings of anger are also natural in connection with serious conditions such as cancer and pain. 3 Anger regulation, referringto how a person usually behaves when feeling angry, is thought to be a fairly stable trait. 4 Anger inhibition (anger-in) reflects a tendency to suppress angry feelings, whereas expression of anger (anger-out) reflects the opposite tendency. Previous studies suggest that anger regulation interrelates with quality of life, 5,6 somatic well-being, 5,7,8 and pain. 9,10 Persistent pain after breast cancer treatments is common. Approximations of the prevalence vary from 14% to 60%. 11,12 Systematic risk factors have been found to include, for example, anxiety, radiotherapy, more invasive surgery, and greater preoperative and acute postoperative pain. 11,12 Research suggests that there is an association between anger regulation and both acute and chronic pain. 9,10,[13][14][15] Compared with anger-in, anger-out has been reported to have a more independent effect on pain. [14][15][16] However, negativ...

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“…Decision tree (DT): DT is a graph-shaped model that represents the decision points as ramifications and the desired prediction as end-nodes or leaves. It is therefore a rule-based model that induces solutions from the decision rules: [258,284,[287][288][289].…”

mentioning

confidence: 99%

Sensor Technologies to Manage the Physiological Traits of Chronic Pain: A Review

Naranjo-Hernández

Reina‐Tosina

Roa

2020

Sensors

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Non-oncologic chronic pain is a common high-morbidity impairment worldwide and acknowledged as a condition with significant incidence on quality of life. Pain intensity is largely perceived as a subjective experience, what makes challenging its objective measurement. However, the physiological traces of pain make possible its correlation with vital signs, such as heart rate variability, skin conductance, electromyogram, etc., or health performance metrics derived from daily activity monitoring or facial expressions, which can be acquired with diverse sensor technologies and multisensory approaches. As the assessment and management of pain are essential issues for a wide range of clinical disorders and treatments, this paper reviews different sensor-based approaches applied to the objective evaluation of non-oncological chronic pain. The space of available technologies and resources aimed at pain assessment represent a diversified set of alternatives that can be exploited to address the multidimensional nature of pain.

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Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy

Cited by 61 publications

References 57 publications

Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung

Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung

The relationship between anger regulation, mood, pain, and pain‐related disability in women treated for breast cancer

Sensor Technologies to Manage the Physiological Traits of Chronic Pain: A Review

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