Machine learning for real-time optical property recovery in interstitial photodynamic therapy: a stimulation-based study

Yassine, Abdul-Amir; Lilge, Lothar; Betz, Vaughn

doi:10.1364/boe.431310

Cited by 13 publications

(10 citation statements)

References 43 publications

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“…These results highlight the importance of careful patient-specific treatment planning for PDT. This has been thoroughly investigated for PDT of cancer, for which multiple investigators have reported treatment planning for sites including head and neck, 33 , 38 , 39 brain, 40 – 42 and prostate 43 – 46 tumors. Largely in the context of interstitial applications, these previous treatment plans focused on determination of the optimal type and number of source optical fibers, as well as the placement and optical power delivered by these fibers.…”

Section: Discussionmentioning

confidence: 99%

Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study

Nguyen

Bass

et al. 2022

J. Biomed. Opt.

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. Significance: Antimicrobial photodynamic therapy (PDT) effectively kills bacterial strains found in deep tissue abscess cavities. PDT response hinges on multiple factors, including light dose, which depends on patient optical properties. Aim: Computed tomography images for 60 abscess drainage subjects were segmented and used for Monte Carlo (MC) simulation. We evaluated effects of optical properties and abscess morphology on PDT eligibility and generated treatment plans. Approach: A range of abscess wall absorptions ( ) and intra-cavity Intralipid concentrations were simulated. At each combination, the threshold optical power and optimal Intralipid concentration were found for a fluence rate target, with subjects being eligible for PDT if the target was attainable with of source light. Further simulations were performed with absorption within the cavity ( ). Results: Patient-specific treatment planning substantially increased the number of subjects expected to achieve an efficacious light dose for antimicrobial PDT, especially with Intralipid modification. The threshold optical power and optimal Intralipid concentration increased with increasing ( ). PDT eligibility improved with patient-specific treatment planning ( ). With , eligibility increased from 42% to 92%. Increasing reduced PDT eligibility ( ); modifying the delivered optical power had the greatest impact in this case. Conclusions: MC-based treatment planning greatly increases eligibility for PDT of abscess cavities.

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Section: Discussionmentioning

confidence: 99%

Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study

Nguyen

Bass

et al. 2022

J. Biomed. Opt.

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“…The pig lung mesh executes slowly as photons frequently cross tetrahedral boundaries, requiring lookup of optical properties in the entered tetrahedron, and frequently cross tissue regions, requiring additional reflection and refraction calculations. Table 4 shows the relative performance of PDT plan optimization via PDT-SPACE using the Colin27 brain atlas and two different tumor cases, one small (

and three light sources) and one large (

and 19 light sources), which are cases T7 and T2 from Yassine et al., 50 respectively. Note that PDT-SPACE currently supports only CPU-based implementations.…”

Section: Fullmontewebmentioning

confidence: 99%

Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE

Wang

Dai

et al. 2022

J. Biomed. Opt.

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. Significance: Open-source software packages have been extensively used in the past three decades in medical imaging and diagnostics, aiming to study the feasibility of the application ex vivo . Unfortunately, most of the existing open-source tools require some software engineering background to install the prerequisite libraries, choose a suitable computational platform, and combine several software tools to address different applications. Aim: To facilitate the use of open-source software in medical applications, enabling computational studies of treatment outcomes prior to the complex in-vivo setting. Approach: FullMonteWeb, an open-source, user-friendly web-based software with a graphical user interface for interstitial photodynamic therapy (iPDT) modeling, visualization, and optimization, is introduced. The software can perform Monte Carlo simulations of light propagation in biological tissues, along with iPDT plan optimization. FullMonteWeb installs and runs the required software and libraries on Amazon Web Services (AWS), allowing scalable computing without complex set up. Results: FullMonteWeb allows simulation of large and small problems on the most appropriate compute hardware, enabling cost improvements of versus always running on a single platform. Case studies in optical property estimation and diffuser placement optimization highlight FullMonteWeb’s versatility. Conclusion: The FullMonte open source suite enables easier and more cost-effective in-silico studies for iPDT.

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“…For the case of light dose deposited in tissue, this is largely determined by the tissue optical properties: absorption and scattering. Multiple studies have shown the importance of patient-specific measures of tissue optical properties for PDT treatment planning purposes [7][8][9], as these can vary widely between individuals [10]. This is particularly true for abscesses, as morphology can be quite distinct between subjects and the integrating sphere effect can result in fluence rates much different than those predicted purely by geometry or diffusion of light [11].…”

Section: Introductionmentioning

confidence: 99%

Preliminary measurements of optical properties in human abscess cavities prior to methylene blue photodynamic therapy

Hannan

Sharma

Baran

2023

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI

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As part of our ongoing Phase 1 clinical trial to establish the safety and feasibility of methylene blue photodynamic therapy (MB-PDT) for human deep tissue abscess cavities, we have shown that determination of abscess wall optical properties is vital for the design of personalized treatment plans aiming to optimize light dose. To that end, we have developed and validated an optical spectroscopy system for the assessment of optical properties at the cavity wall, including a compact fiber-optic probe that can be inserted through the catheter used for the standard of care abscess drainage. Here we report preliminary findings from the first three human subjects to receive these optical spectroscopy measurements. We observed wide variability in concentrations of oxy- and deoxy-hemoglobin prior to MB administration, ranging from 7.3-213 μM and 0.1-47.2 μM, respectively. Reduced scattering coefficients also showed inter-patient variability, but recovered values were more similar between subjects (5.5-10.9 cm-1 at 665 nm). Further, methylene blue uptake was found to vary between subjects, and was associated with a reduction in oxygen saturation. These measured optical properties, along with preprocedure computed tomography (CT) images, will be used with our previously developed Monte Carlo simulation framework to generate personalized treatment plans for individual patients, which could significantly improve the efficacy of MB-PDT while ensuring safety.

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Machine learning for real-time optical property recovery in interstitial photodynamic therapy: a stimulation-based study

Cited by 13 publications

References 43 publications

Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study

Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study

Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE

Preliminary measurements of optical properties in human abscess cavities prior to methylene blue photodynamic therapy

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