2024
DOI: 10.1038/s41598-024-63736-y
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Machine learning survival prediction using tumor lipid metabolism genes for osteosarcoma

Shuai Li,
Zhenzhong Zheng,
Bing Wang

Abstract: Osteosarcoma is a primary malignant tumor that commonly affects children and adolescents, with a poor prognosis. The existence of tumor heterogeneity leads to different molecular subtypes and survival outcomes. Recently, lipid metabolism has been identified as a critical characteristic of cancer. Therefore, our study aims to identify osteosarcoma's lipid metabolism molecular subtype and develop a signature for survival outcome prediction. Four multicenter cohorts—TARGET-OS, GSE21257, GSE39058, and GSE16091—wer… Show more

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