Machine perfusion for cardiac allograft preservation

Cobert, M.L.; West, Lindsey; Jessen, Michael E.

doi:10.1097/mot.0b013e32830fdf9a

Cited by 39 publications

(27 citation statements)

References 49 publications

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“…19 The ability to extend the cardiac donor ischemic interval may allow for long-distance procurements, recovery of older donors, better donor-recipient matching, and even recovery of marginal donors or donation after determination of circulatory death. 17,18,20 A warm, beating-heart technique is undergoing clinical trials in the United States (Organ Care Systems; Transmedics, Inc., Landover, MA) 20 and has recently been used to recover donation after determination of circulatory death donors in selected cases. 21,22 In the current study, we used a large-animal model retrograde cold perfusion technique for long-term preservation of donor hearts.…”

Section: Discussionmentioning

confidence: 99%

Successful transplantation in canines after long-term coronary sinus machine perfusion preservation of donor hearts

Brant¹,

Holmes²,

Cobert³

et al. 2016

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

Successful transplantation in canines after long-term coronary sinus machine perfusion preservation of donor hearts

Brant¹,

Holmes²,

Cobert³

et al. 2016

The Journal of Heart and Lung Transplantation

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“…On the other hand, roughly one-sixth of both the offered hearts and lungs were refused for logistic reasons. In the future, machine perfusion of heart and lung grafts may permit longer preservation times and longer transport distances [12,13], which is of major importance so as not to lose good-quality organs. In a recently published study, median cold ischaemia time in Switzerland ranged from 162 to 179 min for the heart, and from 272.5 to 285 min for the lung [14].…”

Section: Discussionmentioning

confidence: 99%

Assessing the potential of international organ exchange — the Swiss experience

Schneider

Schreiner

Weiss

et al. 2011

European Journal of Cardio-Thoracic Surgery

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International organ exchange is a very valuable and effective way to allocate a maximum of medically suitable organs to recipients on the waiting list. Organ exchange is lifesaving, especially in children, and also in patients with rare blood groups. A professional structure within the national organ procurement organisations, and a close cooperation between them on an international level, is crucial to achieve organ exchange on a high-quality level in Europe.

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“…The potential benefits are many [16,17], since the continuous supply of oxygen and energy substrates facilitate aerobic metabolism, making the application of important hypothermia not viable. Continuous washing of toxic metabolisms occurs, which increases the graft time preservation safely, facilitating logistics, that often seems to be difficult and complex [18,19].…”

Section: Discussionmentioning

confidence: 99%

"Non Working Beating Heart"

Dinkhuysen¹,

Contreras²,

Cipullo³

et al. 2011

Rev Bras Cir Cardiovasc

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Background and Objective: We attempt to reduce the ischemic time during implantation of the donor heart in the bicaval bipulmonary orthotopic position using normothermic beating heart and thus, facilitate the transplanted heart adaptation to the recipient. This study presents a small experience about a new strategy of myocardial protection during heart transplant.Methods: In cardiopulmonary bypass, the aorta anastomosis was done first, allowing the coronary arteries to receive blood flow and the recovering of the beats. The rest of the anastomosis is performed on a beating heart in sinus rhythm. The pulmonary anastomosis is the last to be done. This methodology was applied in 10 subjects: eight males, age 16-69 (mean 32.7 years), SPAo 90-100 mmHg (mean 96 mmHg), SPAP 25-65 mmHg (mean 46.1 mmHg), PVR 0.9 to 5.0 Wood (mean 3.17 Wood), GTP 4-13 mmHg (mean 7.9 mmHg), and eight male donors, age 15-48 years (mean 27.7 years), weight 65-114 kg (mean 83.1 kg). Causes of brain coma: encephalic trauma in five hemorrhagic stroke in four, and brain tumor in one.Results: The ischemic time ranged from 58-90 minutes (mean 67.6 minutes) and eight donors were in hospitals of Sao Paulo and two in distant cities. All grafts assumed the cardiac output requiring low-dose inotropic therapy and maintained these conditions in the postoperative period. There were no deaths and all were discharged. The late evolution goes from 20 days to 10 months with one death occurred after 4 months due to sepsis.Conclusion: This method, besides reducing the ischemic time of the procedure, allows the donated organ to regain and maintain their beats without pre or after load during implantation entailing the physiological recovery of the graft.Descriptors: Ischemia. Heart transplantation. Cardiac surgical procedures. ResumoIntrodução e Objetivo: Trata-se do implante em posição ortotópica bicaval bipulmonar do coração doado batendo em normotermia. Este estudo busca diminuir o tempo isquêmico e criar condições de ir se adaptando ao organismo hospedeiro.Métodos: Já em CEC, a primeira anastomose a ser feita é a da aorta, reperfundindo as artérias coronárias e recuperando os batimentos. As restantes são realizadas com o coração batendo em ritmo sinusal, sendo a da artéria pulmonar a última. Esta metodologia foi aplicada em 10 pacientes receptores, sendo oito do sexo masculino, com RBCCV 44205-1331

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Machine perfusion for cardiac allograft preservation

Cited by 39 publications

References 49 publications

Successful transplantation in canines after long-term coronary sinus machine perfusion preservation of donor hearts

Successful transplantation in canines after long-term coronary sinus machine perfusion preservation of donor hearts

Assessing the potential of international organ exchange — the Swiss experience

"Non Working Beating Heart"

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