Macro- and Microelements in the Cataractous Eye Lens

Stanojević-Paović, Anka; Hristić, Vitomir; Čuperlović, Margita; Jovanović, Slavoljub; Krsmanović, Jovanka

doi:10.1159/000265499

Cited by 18 publications

(16 citation statements)

References 9 publications

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“…Zinc concentration in ocular tissues has been determined by flame or flameless atomic absorption spectrophotometry [37,[43][44][45][46][47][48][49][50][51][52], neutron activation [53,54], X-ray fluorescence [16], electron probe microanalysis [55], inductively coupled plasma-mass spectrometry [56,57] and plasma emission spectrophotometry [58]. The amount of zinc varies greatly with age and the ocular tissue examined; however, the retina and uvea usually contain the highest concentrations (Table 1) [16,37,52,53,56,57,59 -62].…”

Section: Localization and Concentration Of Zinc In The Eyementioning

confidence: 99%

Zinc and the Eye

Grahn

Paterson

Gottschall‐Pass

et al. 2001

Journal of the American College of Nutrition

152

118

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Zinc, a trace element that influences cell metabolism through a variety of mechanisms, appears to play an integral role in maintaining normal ocular function. This element is present in high concentrations in ocular tissue, particularly in retina and choroid. Zinc deficiency has been shown in a number of species to result in a variety of gross, ultrastructural and electrophysiologic ocular manifestations. The physiological functions for zinc have been studied predominantly in retina and retinal pigment epithelium where zinc is believed to interact with taurine and vitamin A. modify photoreceptor plasma membranes, regulate the light-rhodopsin reaction, modulate synaptic transmission and serve as an antioxidant. Suboptimal zinc status in North America may influence the development and progression of several chronic eye diseases. Zinc supplementation trials and epidemiological studies have produced conflicting results concerning the role of zinc in age-related macular degeneration. Additional well-controlled supplementation trials are indicated to clarify the role of zinc in this disease. Future investigations must also expand our understanding of the mechanisms by which zinc regulates ocular morphology and function.

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Section: Localization and Concentration Of Zinc In The Eyementioning

confidence: 99%

Zinc and the Eye

Grahn

Paterson

Gottschall‐Pass

et al. 2001

Journal of the American College of Nutrition

152

118

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“…Osmotic swelling with lens fiber membrane damage and increased uptake of sodium and chloride ions is known to occur in galactoseinduced cataract [1]. Understanding the role of various inorganic ions in cataract formation constitutes an important area of thrust in the field of eye research [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…In cataractous condition, influx of Na + attracts water and chlorine ions paving the way for disturbance of the osmotic balance in the lens environment [3]. In addition, previous reports indicate that accumulation of Ca 2+ and Na + and loss of potassium lead to the impaired permeability of eye lens membrane, resulting in the formation of cataract [10,11] Flavonoids, polyphenolic compounds, found in dietary sources [12] are potent inhibitors of aldose reductase (AR) that play a key role in the development of diabetic cataract.…”

Section: Introductionmentioning

confidence: 99%

Defensive Role of Quercetin Against Imbalances of Calcium, Sodium, and Potassium in Galactosemic Cataract

Ramana

Raju

Kumar

et al. 2007

Biol Trace Elem Res

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Galactosemic cataracts are characterized by electrolyte disturbances resulting in osmotic imbalance and loss of transparency. We have studied the defensive role of quercetin, a bioflavonoid, against the alterations of calcium (Ca2+), sodium (Na+), and potassium (K+) concentrations in galactose-induced cataract in a rodent model. The experimental study was conducted on weanling male Wistar rats with an average body weight of 34 +/- 0.9 g. Different groups received normal stock AIN 93 diet (group A, n = 8), AIN 93 diet with 30% galactose (group B, n = 8), and AIN 93 diet with 30% galactose + quercetin at 400 mg/100 g diet (group C, n = 8). Aldose reductase activity and protein content and concentrations of Ca2+, Na+, and K+ were determined in normal and cataractous lenses. Treatment with quercetin resulted in a significant decrease in Na+ and Ca2+ and aldose reductase levels and an increase in K+ and protein levels in galactosemic cataractous lenses. These results imply that inclusion of quercetin contributes to lens transparency through the maintenance of characteristic osmotic ion equilibrium and protein levels of the lens.

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“…Any imbalance in any of these sensitive constituents may result, directly or indirectly, in lenticular opacification [2,[6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Nickel, Chromium, Manganese, Iron and Aluminum Levels in Human Cataractous and Normal Lenses

Çekıç

Bardak²,

Totan³

et al. 1999

Ophthalmic Res

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Atomic absorption spectrophotometry was used to detect lenticular nickel, chromium, manganese, iron and aluminum levels in 37 senile cataractous and 9 normal human lenses. The nuclear parts of the lenses were used for the study in both groups. It was found that the concentrations of nickel and iron were significantly higher, and those of chromium, manganese and aluminum were significantly lower in human cataractous lenses than those in normal human lenses. None of the elements showed a significant difference according to sex in both groups. As remarkable differences in chromium, manganese, iron, aluminum and nickel levels exist in cataractous lenses, all the five elements may play some roles in cataractogenesis.

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Macro- and Microelements in the Cataractous Eye Lens

Cited by 18 publications

References 9 publications

Zinc and the Eye

Zinc and the Eye

Defensive Role of Quercetin Against Imbalances of Calcium, Sodium, and Potassium in Galactosemic Cataract

Nickel, Chromium, Manganese, Iron and Aluminum Levels in Human Cataractous and Normal Lenses

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