Macro cisterna magna: A marker for maldevelopment of the brain?

Marks, Warren A.; Hamza, M.; Schaefer, Gerald

doi:10.1016/0887-8994(88)90067-7

Cited by 35 publications

(14 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is the significance of IECM that remains most controversial principally as there are contradictory data regarding the postnatal clinical significance of this finding. Although there are reports indicating that IECM is typically associated with infants that are normal at birth and in early infancy [21,22,23,24], other studies suggest that there may be implications relating to neurodevelopment [25,26]. These latter studies suggest that although the developmental assessments of motor function in infants diagnosed with IECM fall within the normal range, they are appreciably poorer than infants in whom the CM had been normal.…”

Section: Discussionmentioning

confidence: 49%

“…Pediatric data also lend support to the suggestion that IECM is not always an entirely benign observation [27]. In one series of patients under the age of 21 in whom neuroimaging was performed for indications that excluded symptoms attributable to posterior fossa disease, 1% were identified as having IECM with 62% of these displaying a developmental or neurological impairment [26]. Additional pertinent data relates to studies evaluating the effects of the forkhead box C1 (FOXC1) gene.…”

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Reassessment of the Normal Fetal Cisterna Magna during Gestation and an Alternative Approach to the Definition of Cisterna Magna Dilatation

Brown¹

2013

Fetal Diagn Ther

View full text Add to dashboard Cite

Introduction: Cisterna magna (CM) measurement constitutes part of the sonographic assessment of the posterior fossa. CM enlargement (ECM) is defined as a measurement exceeding 10 mm, although it has previously been noted that the CM varies in size with gestation. Existing data do not appear to reflect observations regarding CM biometry within our population and this study was therefore undertaken in order to re-evaluate CM biometry. Materials and Methods: Data from 4,750 normal pregnancies between 15 and 32 weeks of gestation were collected and used to construct a reference range for the CM. Results: Regression analysis was used to model CM across gestational age and thereby define the upper limits for normal CM measurements across gestation. The CM increases with gestation. These data suggest that a 10-mm cut-off underestimates ECM, notably in the gestational age period below 24 weeks, whilst overestimating isolated ECM beyond this. Differences in CM measurements between genders were confirmed (p < 0.0001). Conclusions: Defining ECM based upon a cut-off of 10 mm across all gestations may be inappropriate given the variation observed with gestational age. More accurate identification of fetuses with, in particular, isolated ECM may facilitate more precise evaluation of the clinical significance of this finding.

show abstract

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 86%

Reassessment of the Normal Fetal Cisterna Magna during Gestation and an Alternative Approach to the Definition of Cisterna Magna Dilatation

Brown¹

2013

Fetal Diagn Ther

View full text Add to dashboard Cite

show abstract

“…Further examination of the MRI scans revealed that 9 (14%) of the 64 patients with a CSP also had a hypoplastic corpus callosum and 12 ( 19%) had a large cisterna magna [7][8][9]. Review of clinical records of the group with a CSP also revealed that 13 (20%) of the 64 were microcephalic and that only 2 (3%) were macrocephalic.…”

Section: Resultsmentioning

confidence: 99%

The Cavum Septi Pellucidi; A Magnetic Resonance Imaging Study of Prevalence and Clinical Associations in a Pediatric Population

Breeding

Bodensteiner

Cowan

et al. 1991

Journal of Neuroimaging

Self Cite

View full text Add to dashboard Cite

The cavum septi pellucidi is formed when the two leaves of the septum pellucidum fail to fuse as the fetal brain matures. When observed at autopsy or by computed tomography or magnetic resonance imaging (MRI), it is often considered clinically insignificant. Using MRI, this study evaluated the prevalence of cavum septi pellucidi in 445 pediatric patients and correlated the findings to the patients' functional level. A cavum septi pellucidi of 1.3 to 12.0 mm was observed in 64 (14%) of the patients. Of the children with cavum septi pellucidi, 12 (19%) were mentally retarded or severely developmentally delayed and 24 (38%) were less severely handicapped. In a random sample of 64 patients without cavum septi pellucidi from the original population, only 14 (22%) had any functional abnormality. The data suggest that cavum septi pellucidi is clinically significant as a marker for increased risk of disturbed brain function.

show abstract

“…Neuroimaging revealed an enlarged cisterna magna with abnormally shaped posterior fossa in Patient 1 and diffuse abnormal signal lesions in the subcortical white matter in both cases, findings not previously reported in association to scimitar vein anomaly. Notably, enlarged cisterna magna is a marker for complex syndromic malformations [Bodesteiner et al, 1988;Barkovich, 2000]. Only once previously, gross malformations of the cerebral cortex, precisely vertically oriented frontal gyri and rolandic sulcus connected directly with the sylvian fissure, have been described-at autopsy-in a male infant with scimitar vein anomaly who died at the age of 2 months following catheterization procedures [Shadravan et al, 1974].…”

Section: Discussionmentioning

confidence: 99%

Scimitar vein anomaly with multiple cardiac malformations, craniofacial, and central nervous system abnormalities in a brother and sister: Familial scimitar anomaly or new syndrome?

Ruggieri

Abbate

Parano

et al. 2002

American J of Med Genetics Pt A

View full text Add to dashboard Cite

The scimitar vein "syndrome" is an anomaly of lobar aplasia or hypoplasia and total or partial anomalous venous drainage of one lung. We report a brother and sister born to nonconsanguineous Italian parents with a fatal infantile form of scimitar vein anomaly associated to multiple cardiac anomalies. The infants had major craniofacial anomalies. In addition, the boy had iris coloboma and enlarged cisterna magna; both sibs showed poor brain myelination at neuroimaging confirmed by histopathology in the girl. The cardiovascular system in the family members was fully investigated and all results were completely normal. The association of the above craniofacial anomalies has been occasionally mentioned in syndromes with anomalous venous return. The familial occurrence of isolated total anomalous pulmonary venous return has been documented in sibs, first cousins, and through consecutive generations. Familial pulmonary hypoplasia, as an isolated finding, has been observed in siblings and twins. To the best of our knowledge, even though five familial cases of scimitar "syndrome" have been described thus far, the constellation of anomalies shown by these two sibs has not been reported previously. It appears that scimitar vein "syndrome" is not a "syndrome" per se: it is most likely an anomaly of heterogeneous etiology. This family may represent its own novel syndrome of multiple congenital anomalies of which scimitar vein is a component.

show abstract

Macro cisterna magna: A marker for maldevelopment of the brain?

Cited by 35 publications

References 5 publications

Reassessment of the Normal Fetal Cisterna Magna during Gestation and an Alternative Approach to the Definition of Cisterna Magna Dilatation

Reassessment of the Normal Fetal Cisterna Magna during Gestation and an Alternative Approach to the Definition of Cisterna Magna Dilatation

The Cavum Septi Pellucidi; A Magnetic Resonance Imaging Study of Prevalence and Clinical Associations in a Pediatric Population

Scimitar vein anomaly with multiple cardiac malformations, craniofacial, and central nervous system abnormalities in a brother and sister: Familial scimitar anomaly or new syndrome?

Contact Info

Product

Resources

About