Macro-, micro-, and trace element distributions in areca nut, husk, and soil of northeast India

Zote, Lalrinawma; Lalrammawia, Khawlhring; Buragohain, Ananya; Lalrinhlupuii,; Kakki, Bomngam; Lalmuanpuii, Rebecca; Pachuau, Zodinpuia; Vanlalhruaia, John; Muthukumaran, Rajendra Bose; Kumar, Nachimuthu Senthil; Jahau, Lalrintluanga; Sudarshan, M.; Yushin, Nikita; Nekhoroshkov, Pavel; Grozdov, Dmitrii; Sergeeva, Anastasiya; Zinicovscaia, Inga

doi:10.1007/s10661-021-08859-9

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…With arecoline being the most abundant active ingredient, these contents vary in cultivars from different geographical locations and in various processed forms of areca nuts 25 . The nuts are also reported to contain metals like copper, zinc, and manganese 26,27 . Because arecoline and copper are known to play an essential role in the pathogenesis of OSMF and its malignant transformation, we confirmed their presence in our prepared extract before proceeding with further experiments.…”

Section: Discussionsupporting

confidence: 61%

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A comprehensive analysis of metabolomics and lipidomics in areca nut mediated oral submucous fibrosis progression through LCMS and Raman spectroscopy

Verma,

Adhikari,

Singh

et al. 2024

J Raman Spectroscopy

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Habitual consumption of areca/betel nut in Southeast Asia has been associated with oral submucous fibrosis (OSMF) and its malignant transformation to oral squamous cell carcinoma. The current study aimed to assess the molecular alterations in fibroblast cell lines after treatment with areca nut. Areca nut extract (ANE) was prepared and characterized for its active ingredient, arecoline. ANE‐treated cells were subjected to cell viability, proliferation, migration, morphologic changes, and transcript of OSMF genes (col1a1, col1a2, hsp47, timp1, timp2, timp3, and timp4). Further, liquid chromatography–mass spectrometry (LCMS) of cell lysate and Raman microspectroscopy (RMS) of fixed cells were performed for metabolomics/lipidomics and biomolecular alterations in the nucleus and periphery of ANE‐treated cells. We compared and integrated the data from both techniques and observed that the cells treated with ANE mimicked OSMF and could be used as an in vitro model. LCMS showed a significant alteration in 17 metabolites and 165 lipid molecules in the cells treated with ANE. Further, 40 molecules in the nucleus and 29 in the periphery were found to be altered in these cells when subjected to RMS. Molecules associated with pathways such as the transfer of acetyl groups into mitochondria, amino sugar metabolism, and the Warburg effect were modulated the most upon ANE treatment. Acetyl CoA was found to be common in most of the altered pathways. Besides, the pathways affecting carbohydrate metabolism were also altered significantly. Targeting these molecules and pathways can help to prevent the malignant transformation of OSMF.

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Section: Discussionsupporting

confidence: 61%

“…25 The nuts are also reported to contain metals like copper, zinc, and manganese. 26,27 Because arecoline and copper are known to play an essential role in the pathogenesis of OSMF and its malignant transformation, we confirmed their presence in our prepared extract before proceeding with further experiments.…”

Section: Discussionmentioning

confidence: 62%

A comprehensive analysis of metabolomics and lipidomics in areca nut mediated oral submucous fibrosis progression through LCMS and Raman spectroscopy

Verma,

Adhikari,

Singh

et al. 2024

J Raman Spectroscopy

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“…The fatty acids mainly found in areca nut are lauric acid, myristic acid, palmitic acid, stearic acid, and oleic acid [ 27 , 51 ]. In addition, some trace elements have also been identified in areca nut, such as Zn, Fe, Al, Cr, Co, Mn, Cu, and so on [ 68 ].…”

Section: Main Chemical Components Of Areca Nutmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

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Areca catechu L. is a widely cultivated tropical crop in Southeast Asia, and its fruit, areca nut, has been consumed as a traditional Chinese medicinal material for more than 10,000 years, although it has recently attracted widespread attention due to potential hazards. Areca nut holds a significant position in traditional medicine in many areas and ranks first among the four southern medicines in China. Numerous bioactive compounds have been identified in areca nuts, including alkaloids, polyphenols, polysaccharides, and fatty acids, which exhibit diverse bioactive functions, such as anti-bacterial, deworming, anti-viral, anti-oxidant, anti-inflammatory, and anti-tumor effects. Furthermore, they also display beneficial impacts targeting the nervous, digestive, and endocrine systems. This review summarizes the pharmacological functions and underlying mechanisms of the bioactive ingredients in areca nut. This helps to ascertain the beneficial components of areca nut, discover its medicinal potential, and guide the utilization of the areca nut.

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“…2 ) [66] . It has been demonstrated that heavy metal ion cadmium, present at trace levels in lifestyle products ( vide supra ) [102] , [103] , can induce global DNA hypermethylations with the upregulation of DNMT genes ( Fig. 1 ) [12] , [79] .…”

Section: Betel Quid and Its Associated Epigenetic Instabilitymentioning

confidence: 99%

Genetic and epigenetic instability induced by betel quid associated chemicals

et al. 2023

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Macro-, micro-, and trace element distributions in areca nut, husk, and soil of northeast India

Cited by 8 publications

References 48 publications

A comprehensive analysis of metabolomics and lipidomics in areca nut mediated oral submucous fibrosis progression through LCMS and Raman spectroscopy

A comprehensive analysis of metabolomics and lipidomics in areca nut mediated oral submucous fibrosis progression through LCMS and Raman spectroscopy

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Genetic and epigenetic instability induced by betel quid associated chemicals

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