Macro-microporous ZIF-8 MOF complexed with lysosomal pH-adjusting hexadecylsulfonylfluoride as tumor vaccine delivery systems for improving anti-tumor cellular immunity

Abstract

Tumor vaccine therapy, which can induce tumor antigens-specific cellular immune responses to directly kill tumor cells, is considered to be one of the most promising tumor immunotherapies. How to elicit...

Palmitic acid-capped MIL-101-Al as a nano-adjuvant to amplify immune responses against Pseudomonas aeruginosa

“…Studies have reported that efficient endo –lysosomal escape of an antigen can promote antigen cross-presentation to greatly improve MHC-I presentation for CD8 + T cells priming. 35 Thus the ability of MIL-BC@PAA to effect cytosolic delivery was clarified on BMDCs using confocal microscopy. Almost all the red (antigen) and green fluorescence (lysosomal) signals overlapped at 1 h incubation, and nearly negligible discrete fluorescence signal could be seen (Fig.…”

A new era in cancer treatment: harnessing ZIF-8 nanoparticles for PD-1 inhibitor delivery

“…In the context of this study, ZIF-8 nanoparticles served as an instrumental drug carrier for precise and targeted delivery in the realm of cancer therapy. 23,114–122…”

Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers: From Synthesis to Cancer Therapy and Biomedical Imaging

“…In the evolving landscape of the biomedical field, strategies including chemotherapy, photodynamic therapy, photothermal therapy, chemical dynamic therapy, and combination therapy have demonstrated significant potential in cancer treatment. ,, However, these approaches remain challenges in clinical implementation, including nonspecific distribution and unfavorable pharmacokinetics, resulting in undesirable high doses and causing toxicity to the body. Many research suggests that NMOFs and NCPs are highly promising nanocarriers for delivering therapeutic agents to the tumor sites. ,, This provides a means to achieve enhanced therapeutic effects at low doses.…”