Macroalgal activity against fungal urinary tract infections: in vitro screening and evaluation study

Zawawy, Nessma El; Shafay, Shimaa El; Abomohra, Abd El‐Fatah

doi:10.1007/s12210-019-00856-y

Cited by 11 publications

(5 citation statements)

References 37 publications

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“…These strains were identified as P. aeruginosa PA-02, P. aeruginosa PA-09, Escherichia coli EC-03, Klebsiella pneumonia KP-01, S. aureus SA-03, and S. aureus SA-04, as we previously reported [ 5 , 6 , 57 ]. Screening of antibacterial activity of LT against the tested bacterial strains was estimated by the agar well diffusion method, as described previously in detail with a minor modification [ 60 ]. Culture suspensions of bacterial strains were prepared to contain 10 6 CFU/ml, and the agar plates were inoculated with 100 µl of the broth cultures of the tested strains.…”

Section: Methodsmentioning

confidence: 99%

Exploring the potential of Rhizopus oryzae AUMC14899 as a novel endophytic fungus for the production of l-tyrosine and its biomedical applications

2023

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Background A significant threat to the public's health is the rise in antimicrobial resistance among numerous nosocomial bacterial infections. This may be a detriment to present initiatives to enhance the health of immune-compromised patients. Consequently, attention has been devoted to exploring new bioactive compounds in the field of drug discovery from endophytes. Therefore, this study is the first on the production of l-tyrosine (LT) as a promising bio-therapeutic agent from endophytic fungi. Results A new endophytic fungal isolate has been identified for the first time as Rhizopus oryzae AUMC14899 from Opuntia ficus-indica (L.) and submitted to GenBank under the accession number MZ025968. Separation of amino acids in the crude extract of this fungal isolate was carried out, giving a higher content of LT, which is then characterized and purified. LT exhibited strong antibacterial and anti-biofilm activities against multidrug-resistant Gram-negative and Gram-positive bacteria. The recorded minimum inhibitory concentration (MIC) values ranged from 6 to 20 µg/ml. In addition, LT caused a strong reduction in biofilm formation and disrupted the preformed biofilm. Moreover, results indicated that LT supported cell viability, evidencing hemocompatibility and no cytotoxicity. Conclusion Our findings suggest that LT has potential as a therapeutic agent due to its potential antibacterial, anti-biofilm, hemocompatibility, and lack of cytotoxic activities, which may also increase the range of therapy options for skin burn infections, leading to the development of a novel fungal-based drug.

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Section: Methodsmentioning

confidence: 99%

Exploring the potential of Rhizopus oryzae AUMC14899 as a novel endophytic fungus for the production of l-tyrosine and its biomedical applications

2023

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“…The potential of seaweed as an antifungal agents was tested some decades back in several countries worldwide (125). Reports of adoption of seaweed extract as antifungal agent in agriculture are available (126).…”

Section: Antifungal Propertiesmentioning

confidence: 99%

A Review on Seaweed Farming in Western Indian Ocean: Benefits and Challenges

RIPANDA,

Mtenga

2024

Preprint

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Seaweed farming in the Western Indian Ocean (WIO) is among the income-generating activities; apart from seaweeds being primary producers, they are foundation species important for marine ecosystem capable of modifying their surrounding abiotic and biotic environments. The WIO coast provides natural and necessary environments for seaweeds farming. In this review article seaweed farming in WIO was investigated; its contribution to provision of ecosystem services; medicinal and nutritional value; role of women; challenges and the wellbeing of farmers and the whole ecosystem. It was observed that among the challenges facing seaweed farmers include lack of modernized farming tools hence farmers use low depth areas leading to attack by diseases, death of seaweed, low yields, and income. Farmers has been reported to be affected by diseases which may be contributed by inadequate of use of protective gears, indicating the need for knowledge on personal protection. This may be contributed by lack of knowledge which leads to farmers participation without using protective equipment leading to contamination from toxic chemical compounds from seaweed, epiphytic bacteria or harmful algal bloom and absorbed heavy metals from seawater as a result of long-term exposure. Farming practices such as uprooting of seaweeds during farm preparation have been observed to cause degradation and decrease fish population. Therefore, there is the need for use of modern technologies; supervision of these activities by professionals in the field, and provision of knowledge to farmers for the sustainability of WIO marine ecosystem.

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“…For decades, seaweed has been discussed as a potential natural source of antimicrobial products that may help curb antibiotic resistance in livestock [153,154]. Various studies attributed the antimicrobial and other biological activities of seaweed to polyphenolic compounds [153,155].…”

Section: Challenges Associated With Marine Biogas Productionmentioning

confidence: 99%

Integrated Marine Biogas: A Promising Approach towards Sustainability

et al. 2022

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Fossil fuel depletion, climate change, and increased global energy demands are the driving forces to find alternative sources of energy. Marine-based biorefinery has been recently discussed as a promising route to mitigate the environmental challenges, enhance the energy recovery, and provide a potential source for value-added products. Anaerobic digestion is a promising technology that can convert the organic compounds of marine ecosystems into biogas. To date, a comprehensive review incorporating integrated biogas potential and effective approaches to enhance seaweed digestibility for biogas production from marine resources has not been reported. Thus, the present review aims to explore and comprehensively present seaweed and other marine resources for potential biogas production. The basics and challenges of biogas production from seaweed are elucidated. The impact of biochemical composition on biogas and the microbial communities involved in anaerobic digestion of seaweed are discussed. Utilization of different techniques such as pretreatment, co-digestion, and sequential extraction of seaweed biomass to enhance the biogas yield and to mitigate the effect of inhibitors are presented. Specifically, this article evaluates the co-digestion of seaweed with other biomass feedstocks or liquid biowastes. Integration of marine microalgae cultivation on anaerobic digestate for value-added compound production, biogas upgrading, and bioenergy recovery provides a promising approach towards a zero-waste marine-based system.

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Macroalgal activity against fungal urinary tract infections: in vitro screening and evaluation study

Cited by 11 publications

References 37 publications

Exploring the potential of Rhizopus oryzae AUMC14899 as a novel endophytic fungus for the production of l-tyrosine and its biomedical applications

Exploring the potential of Rhizopus oryzae AUMC14899 as a novel endophytic fungus for the production of l-tyrosine and its biomedical applications

A Review on Seaweed Farming in Western Indian Ocean: Benefits and Challenges

Integrated Marine Biogas: A Promising Approach towards Sustainability

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