Macroamylasemia: A Biochemical or Clinical Problem?

Gossum, A. Van

doi:10.1159/000171203

Cited by 8 publications

(13 citation statements)

References 20 publications

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“…The binding site is usually to Fab portion of immunoglobulin. Macrocomplexes with IgM, IgE or IgE have not been identified though other molecules including α 1 antitrypsin, polysaccharides and glycoproteins have been implicated 14. Normally, amylase with molecular mass of approximately 55000 Daltons, is readily filtered by the renal glomeruli.…”

Section: Discussionmentioning

confidence: 99%

A very high amylase can be benign in paediatric Crohn's disease

et al. 2012

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A 12.5-year-old boy with Crohn's disease with abdominal pain had a raised amylase of 1835 IU/l with normal lipase levels. Ultrasound showed no evidence of inflammation of pancreas. The amylase to creatinine clearance ratio, was 0.8% (reference interval 2%-5%; >6% consistent with acute pancreatitis; <1.6% with macroamylasemia), suggesting he had raised serum amylase with a corresponding reduced clearance of amylase in his urine, positively supporting the diagnosis of macroamylasemia. Macroamylasemia has no clinical significance other than misdiagnosis as acute pancreatitis. Awareness of this condition is important and a positive diagnosis should always be made to avoid unnecessary changes in treatments.

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Section: Discussionmentioning

confidence: 99%

A very high amylase can be benign in paediatric Crohn's disease

et al. 2012

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“…Sub-sequent cases have been reported, associated with malignant diseases and other conditions, but also in healthy subjects (1). No macroamylasemia was found in 100 cord blood samples investigated by Barrows in 1972 (1).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The disorder has been reported worldwide and in all human races (1). The first patient reported by Wilding was an adult patient with celiac disease, and 4 of the first 10 patients in the literature had malabsorption (1). Subsequent cases have been reported, associated with malignant diseases and other conditions, but also in healthy subjects (1).…”

Section: Discussionmentioning

confidence: 99%

“…It consists of an elevated serum amylase and a decreased urine amylase resulting from the presence of a macromolecular complex with a molecular weight of 150,000 to 2,000,000 d which is not filtered into the urine. Three different types of macroamylasemia have been described (1). In type 1, amylases as well macroamylases in the serum are elevated, whereas the urinary amylases are decreased.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Disappearance of Macroamylasemia in a Celiac Patient After Treatment With a Gluten‐Free Diet

Deprettere,

Eykens,

Van Hoof

2001

J. pediatr. gastroenterol. nutr.

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Macroamylasemia associated with ulcerative colitis

et al. 1995

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We describe a very rare case in which macroamylasemia was associated with ulcerative colitis of total colitis type. The patient's serum amylase isozyme pattern by electrophoresis showed a broad abnormal peak toward the side of the positive pole compared with regular salivary and pancreatic fractions. Sephadex G-200 column chromatography showed a sedimentation coefficient of 6.6 S. Amylase activity was bound to IgG. Double diffusion experiments demonstrated that amylase activity could be precipitated in gel by an antibody to the lambda chain. Although inflammatory bowel disease is occasionally associated with hyperamylasemia due to pancreatitis, we emphasize that, when hyperamylasemia is recognized in patients with inflammatory bowel disease, macroamylasemia also should be considered.

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Macroamylasemia: A Biochemical or Clinical Problem?

Cited by 8 publications

References 20 publications

A very high amylase can be benign in paediatric Crohn's disease

A very high amylase can be benign in paediatric Crohn's disease

Disappearance of Macroamylasemia in a Celiac Patient After Treatment With a Gluten‐Free Diet

Macroamylasemia associated with ulcerative colitis

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