Macroamylasemia and Celiac Disease in a 6 -Year-Old Girl – Case Report

Abstract

Macroamylasemia is a biochemical disorder, resulting from circulation of macroamylase complexes in which amylase is bound to other macromolecules like immunoglobulins and polysaccharides, which increases their molecular weight, reducing renal excretion of these macromolecules and makes patients have chronically elevated serum amylase levels. Several diseases in association with macroamylasemia have been described, including celiac disease, in which macroamylasemia disappeared once the patients followed a gluten-free diet. We reported a pediatric case of macroamylasemia as a manifestation of celiac disease.

Significant elevations of serum amylase caused by macroamylase: Case reports and detection possibilities

“…Macroamylase is rarely associated with celiac disease, 12 , 22 , 23 pancreatitis 24 and autoimmune diseases. 25 , 26 According to the described cases with celiac disease by Humphrey et al and Velmishi et al, 27 , 28 macroamylase disappeared in the patient serum during gluten‐free diet. On the other hand, the cause of the presence of macroamylase in serum is still unknown; macroenzymes have also been found in patients with malignancy.…”